Browsing by Author "Oliveira, Rita"
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- A administração na mucosa bucal como uma estratégia alternativa à via oralPublication . Dias, Sandra; Figueiras, Ana; Barata, Pedro; Oliveira, Rita; Santos, Delfim; Veiga, Franciscoo principal objectivo deste trabalho foi realizar uma revisão geral sobre o mecanismo de mucoadesão, tendo em consideração aspectos tais como, as teorias explicativas de tal mecanismo, assim como os passos envolvidos no mecanismo de acção. De seguida, foi feita uma abordagem sobre polímeros bioadesivos, tendo sido expostos alguns resultados práticos no sentido de avaliar a força bioadesiva, o trabalho bioadesivo, bem como índice de swelling, de forma a obter uma matriz mucoadesiva com características optimizadas.
- Aplicação de ciclodextrinas na promoção da adesão à terapêutica dermatológica com corticosteroidesPublication . Garrido, Manuela; Oliveira, Bárbara; Oliveira, Rita; Almeida, Isabel; Garrido, Jorge
- Chapter 5: Stimuli-responsive nanosystems for drug-targeted deliveryPublication . Lopes, Carla Martins; Barata, Pedro; Oliveira, Rita
- Ciclodextrinas: formação de complexos e sua aplicação farmacêuticaPublication . Oliveira, Rita; Santos, Delfim; Barata, PedroO número de moléculas com problemas de solubilidade, biodisponibilidade e permeabilidade tem vindo a aumentar. As ciclodextrinas são oligossacarídeos cíclicos com uma cavidade central hidrófoba, cuja estrutura permite formar complexos de inclusão estáveis com diversos fármacos. A complexação com ciclodextrinas permite optimizar os diversos sistemas transportadores constituídos por este tipo de fármacos, assim como solucionar problemas devidos a propriedades indesejáveis como instabilidade, más características organolépticas ou potencial irritação. The number of molecules with problems of solubility, bioavailability and permeability is increasing. Cyclodextrins are cyclic oligosaccharides with a hydrophobic central cavity, whose structure can form stable inclusion complexes with various drugs. Complexation allows the optimization of drug delivery of such drugs, and to solve problems due to undesirable properties such as instability, poor organoleptic characteristics or irritation.
- Cronoterapia: estratégia futura para a libertação de fármacosPublication . Barata, Pedro; Lopes, Carla Martins; Santos, D.; Oliveira, Rita; Murias, I.; Veiga, F.O conhecimento da existência de variações fisiológicas ao longo de um período de 24 horas (variação circadiana) em vários sistemas do organismo humano tem sido explorado por parte da Indústria Farmacêutica no sentido de adaptar a administração de medicamentos de acordo com as necessidades biológicas. Deste modo, estão descritos diversos estudos que demonstram resultados eficazes da aplicação da cronoterapia no controlo de várias doenças (e.g. gastrointestinais, cardiovasculares, respiratórias, no cancro).
- Current neurogenic and neuroprotective strategies to prevent and treat neurodegenerative and neuropsychiatric disordersPublication . Carvalho, I. M.; Barata, Pedro; Costa, P. C.; Marques, C. S.; Oliveira, Rita; Ferreira, D. C.The adult central nervous system is commonly known to have a very limited regenerative capacity. The presence of functional stem cells in the brain can therefore be seen as a paradox, since in other organs these are known to counterbalance cell loss derived from pathological conditions. This fact has therefore raised the possibility to stimulate neural stem cell differentiation and proliferation or survival by either stem cell replacement therapy or direct administration of neurotrophic factors or other proneurogenic molecules, which in turn has also originated regenerative medicine for the treatment of otherwise incurable neurodegenerative and neuropsychiatric disorders that take a huge toll on society. This may be facilitated by the fact that many of these disorders converge on similar pathophysiological pathways: excitotoxicity, oxidative stress, neuroinflammation, mitochondrial failure, excessive intracellular calcium and apoptosis. This review will therefore focus on the most promising achievements in promoting neuroprotection and neuroregeneration reported to date.
- Cyclodextrin-based carriers for topical delivery of anti-inflammatory agentsPublication . Oliveira, Rita; Barata, PedroAnti-inflammatory agents topically applied are appropriate in the treatment of skin diseases, restricting the therapeutical action to the affected area and reducing systemic side effects. On the other hand, systemic activity is the aim of transdermal delivery, which can be used to minimize the first pass metabolism but also to control systemic side effects, e.g., nonsteroidal anti-inflammatory drugs. The main limitation of this route is to overcome the stratum corneum, the outermost skin barrier. In order to achieve therapeutic concentrations and to improve the drug flux, permeation enhancers are used to optimize drug permeation through the skin. Cyclodextrins and their derivatives are capable of forming inclusion complexes with poor water soluble drugs improving their water solubility, bioavailability and stability, among other features. Cyclodextrins have been used as permeation enhancers although their mechanism it not yet well known. They can also be useful in the design of new drug carriers for skin delivery, by increasing the solubility of drugs hence providing high drug content systems. Improving the drug stability and promoting drug permeation are also desirable properties that cyclodextrins can provide to novel drug carriers. Several anti-inflammatory drugs have been incorporated into various skin delivery cyclodextrin-based systems such as liposomes, solid lipid nanoparticles and microemulsions.
- Development of an in vitro test for the evaluation of the sweat-resistance efficacy of decorative cosmetics – an exploratory studyPublication . Costa, Silvana; Oliveira, Rita; Sousa-Lobo, José Manuel; Almeida, Isabel
- Dispensa de produtos fitoterápicos na farmácia comunitáriaPublication . Oliveira, Rita; Lopes, Carla Martins; Barata, Pedro
- Does microbiota influence the risk of childhood obesity?Publication . Oliveira, Rita; Barata, Pedro; Lozano Estevan, María del CarmenChildhood obesity is associated to incremented risk of developing diseases such as diabetes, cardiovascular diseases, or cancer, later in life. Several factors affect infant weight gain such as genetics, maternal lifestyle, and other environmental factors. Perinatal period is considered to be the most important one when defining metabolic programming of the future adult. Several previous researches have discussed the role that gut microbiota might play on obesity risk and its development between 3-5 years old. Again, perinatal period is crucial to define quantity and diversity of a healthy intestinal microbiota. Maternal diet/BMI, delivery mode, antibiotic exposure and breastfeeding are some of the processes that will determine a favorable gut microbiota. Functions of gut microbiota, mostly by producing short-chain fatty acids as metabolites, include regulation of metabolism and immune system of the host, which may be compromised in case of dysbiosis. This review pretends to evaluate the state of the art concerning infant obesity and the role of gut microbiota. Despite the large amount of scientific publications, there is still much work to do regarding the clarification of mechanisms and the possible therapy for childhood obesity.