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Biomarcadores de contaminaĆ§Ć£o ambiental

2016-11-08Master thesis Open access
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datacite.subject.fosCiĆŖncias MĆ©dicas::Medicina BĆ”sicapt_PT
dc.contributor.advisorCarvalho, MƔrcia
dc.contributor.authorSilva, Ana CecĆ­lia de Abreu
dc.date.accessioned2017-02-15T10:53:08Z
dc.date.available2017-02-15T10:53:08Z
dc.date.issued2016-11-08
dc.description.abstractA presenƧa de um xenobiĆ³tico no ambiente representa sempre um risco para os organismos vivos e para o meio onde estes habitam. Um dos mĆ©todos para avaliar a exposiĆ§Ć£o aos xenobiĆ³ticos e o seu potencial impacto sobre os seres vivos baseia-se na utilizaĆ§Ć£o dos chamados biomarcadores. Estes podem fornecer indicaƧƵes da exposiĆ§Ć£o, efeito e suscetibilidade individual a compostos quĆ­micos ambientais e sĆ£o ferramentas muito Ćŗteis para avaliar e controlar o risco de danos a longo prazo associados Ć  exposiĆ§Ć£o a xenobiĆ³ticos, tais como metais pesados, hidrocarbonetos halogenados, pesticidas, fĆ”rmacos, entre outros. Este trabalho pretendeu realizar uma revisĆ£o bibliogrĆ”fica atual sobre a importĆ¢ncia dos biomarcadores na monitorizaĆ§Ć£o ambiental, focando-se nos seguintes aspetos: definiĆ§Ć£o e Ć”reas de aplicabilidade, vantagens e limitaƧƵes, e tipos de biomarcadores: de danificaĆ§Ć£o oxidativa, de neurotoxicidade, de biotransformaĆ§Ć£o, de desregulaĆ§Ć£o endĆ³crina, histopatolĆ³gicos e de genotoxicidade.pt_PT
dc.description.abstractThe presence of xenobiotic compounds in the environment always poses a risk to its inhabitants and to their habitat. One of the methods used to evaluate the exposure to these compounds and their potential impact on living organisms is through the use of biomarkers. They are able to provide information about the nature of the exposure, effects and individual susceptibility to environmental chemical compounds and are also very useful tools to evaluate and control the long-term damage caused by exposure to xenobiotics, such as heavy metals, halogenated hydrocarbons, pesticides, drugs, among others. This work aimed to perform an up-to-date literature review on the importance of biomarkers in environmental monitoring focused on the following issues: definition and areas of applicability, advantages and limitations, and types of biomarkers: of oxidative damage, neurotoxicity, biotransformation, endocrine disruption, of histological damage, and genotoxicity.pt_PT
dc.identifier.tid202652785
dc.identifier.urihttp://hdl.handle.net/10284/5821
dc.language.isoporpt_PT
dc.subjectBiomarcador ambientalpt_PT
dc.subjectPoluentept_PT
dc.subjectXenobiĆ³ticopt_PT
dc.subjectBiomarcador de exposiĆ§Ć£opt_PT
dc.subjectBiomarcador de efeitopt_PT
dc.subjectBiomarcador de suscetibilidadept_PT
dc.subjectEnvironmental biomarkerpt_PT
dc.subjectPollutantpt_PT
dc.subjectXenobioticpt_PT
dc.subjectBiomarker of exposurept_PT
dc.subjectBiomarker of effectpt_PT
dc.subjectBiomarker of susceptibilitypt_PT
dc.titleBiomarcadores de contaminaĆ§Ć£o ambientalpt_PT
dc.typemaster thesis
dspace.entity.typePublication
rcaap.rightsopenAccesspt_PT
rcaap.typemasterThesispt_PT
thesis.degree.nameMestrado Integrado em CiĆŖncias FarmacĆŖuticaspt_PT

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