Loading...
Publication
CaracterizaĆ§Ć£o e patogenecidade de Chlamydia trachomatis
| Name: | Description: | Size: | Format: | |
|---|---|---|---|---|
| PPG_16804 | 575.78 KB | Adobe PDF |
Advisor(s)
Abstract(s)
As infeƧƵes por Chlamydia trachomatis sĆ£o uma grande preocupaĆ§Ć£o em termos de saĆŗde
pĆŗblica, globalmente. Particularmente, a grande preocupaĆ§Ć£o Ć© o facto de que a maioria das
pessoas com infeĆ§Ć£o ano-genital por C. trachomatis sĆ£o assintomĆ”ticas e consequentemente
sem conhecimento que possuem a infeĆ§Ć£o (Lanjouw et al., 2015). Apesar de ser uma infeĆ§Ć£o
silenciosa, na grande maioria das vezes, a sua repercussĆ£o pode ser drĆ”stica, associando-se a
doenƧa inflamatĆ³ria pĆ©lvica, dor pĆ©lvica crĆ³nica, infertilidade, aborto e parto prematuro
(Silva et al., 2009).
Estudos com sistemas de expressĆ£o heterogĆ©neos revelaram que vĆ”rias proteĆnas clamidiais
sĆ£o potencialmente translocadas para o citoplasma do hospedeiro. Ao longo de novas
observaƧƵes biolĆ³gicas das cĆ©lulas e da funĆ§Ć£o dessas proteĆnas, comeƧam a aparecer
hipĆ³teses de esclarecimento sobre como a bactĆ©ria manipula as cĆ©lulas mamĆferas, incluindo
o seu ciclo de desenvolvimento e efeito sobre a imunidade inata (Valdivia, 2008).
Quanto ao diagnĆ³stico na prĆ”tica mĆ©dica, os exames mais usados sĆ£o os seguintes (Marques
e Menezes, 2005): coloraĆ§Ć£o pela tĆ©cnica de Giemsa; citologia pela tĆ©cnica de Papanicolau;
histopatologia; imunofluorescĆŖncia direta; mĆ©todos imunoenzimĆ”ticos como, por exemplo
ELISA; deteĆ§Ć£o de anticorpos (nĆ£o Ć© utilizado em infeƧƵes superficiais como uretrite e
cervicite); tƩcnicas de biologia molecular, como PCR.
O tratamento passa por antibioterapia com azitromicina 1g (toma Ćŗnica), ou doxiciclina
500mg (12/12h), ou ainda eritromicina (estearato) 500mg. No caso de recidiva, recorre-se a
eritromicina 500mg (6/6h) e metronidazol 2g (toma Ćŗnica) (Moherdaui, 2000).
Chlamydia trachomatis infections are major public health concerns globally. Of particular grave concern is that the majority of persons with anogenital Chlamydia trachomatis infections are asymptomatic and accordingly not aware of their infection (Lanjouw et al., 2015). Although it is a silent infection in most cases, its impact can have drastic repercussions, associated with pelvic inflammatory disease, chronic pelvic pain, infertility, miscarriage and premature birth (Silva et al., 2009) Studies with heterologous expression systems have revealed a large set of chlamydial proteins that are potentially translocated into the host cytoplasm. Through new cell biological observations and these proteins function, hypothesis about how the bacteria manipulates mammal cells star to appear, including the cell cycle and innate immunity effect (Valdivia, 2008). Regarding diagnosis in medical practice, the most commonly used tests are the following (Marques e Menezes, 2005): Giemsa staining technique; cytology by Papanicolaou technique; histopathology; direct immunofluorescence; immunoenzymatic methods such as ELISA; antibody detection (not used on superficial infections such as cervicitis and urethritis); molecular biology techniques such as PCR. The treatment involves antibiotic like azithromycin 1g (single dose) or doxycycline 500mg (12 / 12h) or erythromycin (stearate) 500mg. In case of recurrence, refers to erythromycin 500mg (6 / 6h) and 2 g metronidazole (single dose) (Moherdaui, 2000).
Chlamydia trachomatis infections are major public health concerns globally. Of particular grave concern is that the majority of persons with anogenital Chlamydia trachomatis infections are asymptomatic and accordingly not aware of their infection (Lanjouw et al., 2015). Although it is a silent infection in most cases, its impact can have drastic repercussions, associated with pelvic inflammatory disease, chronic pelvic pain, infertility, miscarriage and premature birth (Silva et al., 2009) Studies with heterologous expression systems have revealed a large set of chlamydial proteins that are potentially translocated into the host cytoplasm. Through new cell biological observations and these proteins function, hypothesis about how the bacteria manipulates mammal cells star to appear, including the cell cycle and innate immunity effect (Valdivia, 2008). Regarding diagnosis in medical practice, the most commonly used tests are the following (Marques e Menezes, 2005): Giemsa staining technique; cytology by Papanicolaou technique; histopathology; direct immunofluorescence; immunoenzymatic methods such as ELISA; antibody detection (not used on superficial infections such as cervicitis and urethritis); molecular biology techniques such as PCR. The treatment involves antibiotic like azithromycin 1g (single dose) or doxycycline 500mg (12 / 12h) or erythromycin (stearate) 500mg. In case of recurrence, refers to erythromycin 500mg (6 / 6h) and 2 g metronidazole (single dose) (Moherdaui, 2000).
Description
Keywords
Chlamydia trachomatis DoenƧas sexualmente transmissĆveis Morfologia DiagnĆ³stico Antibioterapia Chlamydia trachomatis Sexually transmitted diseases Morphology Diagnosis Antibiotics