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Bioactive compounds from marine macroalgae in the treatment and prevention of neurodegenerative diseases
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Orientador(es)
Resumo(s)
To date, neurodegenerative diseases, such as Alzheimer’s and Parkinson’s diseases, have no cure. The identification of natural compounds that can be used to treat and prevent neurodegeneration is of growing scientific interest. Marine macroalgae are associated with added value in the areas of therapeutics, food, and industry, and are unexplored sources of bioactive compounds including phlorotannins, terpenes, pigments, phytosterols, and polysaccharides, with beneficial properties for human health. Their antioxidant, anti-inflammatory, and anti-amyloidogenic properties increasingly reinforce their great neuroprotective potential, acting to protect against oxidative stress, neuroinflammation, and mitochondrial dysfunction, which are related to the pathophysiology of neurodegenerative diseases. Few compounds from marine macroalgae have been studied in clinical trials to date. However, the recent approval in China by the National Medical Products Administration of a marine macroalgae oligosaccharide, sodium oligomannate, for the treatment of Alzheimer’s disease has paved the way for the discovery of drugs with potential for the treatment and prevention of neurodegenerative diseases based on marine macroalgae. This manuscript reviews the mechanisms of neurodegeneration characteristic of diseases such as Alzheimer’s and Parkinson’s diseases, and the bioactive compounds of marine macroalgae that exhibit neuroprotective effects, as well as their application in the treatment and prevention of neurodegenerative diseases.
Descrição
Palavras-chave
Bioactive compounds Marine macroalgae Neurodegenerative diseases Alzheimer’s disease Parkinson’s disease
Contexto Educativo
Citação
Leal, M. F. C., Duarte, R. J. G., Cardoso, I. L., Catarino, R. I. L., Pimenta, A. M., & Souto, M. R. S. (2025). Bioactive compounds from marine macroalgae in the treatment and prevention of neurodegenerative diseases. Neurophysiology. https://doi.org/10.1007/s11062-025-09953-1
Editora
Springer Nature
Licença CC
Sem licença CC