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Bioactive compounds from marine macroalgae in the treatment and prevention of neurodegenerative diseases

2025-07-10Recensão Acesso aberto
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datacite.subject.fosCiências Médicas
datacite.subject.sdg03:Saúde de Qualidade
dc.contributor.authorC. Leal, M. Fernanda
dc.contributor.authorDuarte, Rúben Jorge Guedes
dc.contributor.authorLopes Cardoso, Inês
dc.contributor.authorCatarino, Rita
dc.contributor.authorPimenta, Adriana
dc.contributor.authorSouto, Renata
dc.date.accessioned2026-05-08T09:31:18Z
dc.date.available2026-05-08T09:31:18Z
dc.date.issued2025-07-10
dc.description.abstractTo date, neurodegenerative diseases, such as Alzheimer’s and Parkinson’s diseases, have no cure. The identification of natural compounds that can be used to treat and prevent neurodegeneration is of growing scientific interest. Marine macroalgae are associated with added value in the areas of therapeutics, food, and industry, and are unexplored sources of bioactive compounds including phlorotannins, terpenes, pigments, phytosterols, and polysaccharides, with beneficial properties for human health. Their antioxidant, anti-inflammatory, and anti-amyloidogenic properties increasingly reinforce their great neuroprotective potential, acting to protect against oxidative stress, neuroinflammation, and mitochondrial dysfunction, which are related to the pathophysiology of neurodegenerative diseases. Few compounds from marine macroalgae have been studied in clinical trials to date. However, the recent approval in China by the National Medical Products Administration of a marine macroalgae oligosaccharide, sodium oligomannate, for the treatment of Alzheimer’s disease has paved the way for the discovery of drugs with potential for the treatment and prevention of neurodegenerative diseases based on marine macroalgae. This manuscript reviews the mechanisms of neurodegeneration characteristic of diseases such as Alzheimer’s and Parkinson’s diseases, and the bioactive compounds of marine macroalgae that exhibit neuroprotective effects, as well as their application in the treatment and prevention of neurodegenerative diseases.eng
dc.identifier.citationLeal, M. F. C., Duarte, R. J. G., Cardoso, I. L., Catarino, R. I. L., Pimenta, A. M., & Souto, M. R. S. (2025). Bioactive compounds from marine macroalgae in the treatment and prevention of neurodegenerative diseases. Neurophysiology. https://doi.org/10.1007/s11062-025-09953-1
dc.identifier.doi10.1007/s11062-025-09953-1
dc.identifier.issn1573-9007, 0090-2977
dc.identifier.urihttp://hdl.handle.net/10284/15404
dc.language.isoeng
dc.peerreviewedyes
dc.publisherSpringer Nature
dc.relation.hasversionhttps://link.springer.com/article/10.1007/s11062-025-09953-1
dc.rights.uriN/A
dc.subjectBioactive compounds
dc.subjectMarine macroalgae
dc.subjectNeurodegenerative diseases
dc.subjectAlzheimer’s disease
dc.subjectParkinson’s disease
dc.titleBioactive compounds from marine macroalgae in the treatment and prevention of neurodegenerative diseaseseng
dc.typereview
dspace.entity.typePublication
oaire.citation.endPage30
oaire.citation.startPage8
oaire.citation.titleNeurophysiology
oaire.citation.volume55
oaire.versionhttp://purl.org/coar/version/c_970fb48d4fbd8a85
person.familyNameC. Leal
person.familyNameLopes Cardoso
person.familyNameCatarino
person.familyNamePimenta
person.familyNameSouto
person.givenNameM. Fernanda
person.givenNameInês
person.givenNameRita
person.givenNameAdriana
person.givenNameRenata
person.identifier2210421
person.identifier1584168
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person.identifier.orcid0000-0001-9010-2921
person.identifier.orcid0000-0003-1975-5094
person.identifier.orcid0000-0002-2130-8667
person.identifier.ridM-7156-2013
person.identifier.ridD-6597-2013
person.identifier.ridD-6248-2013
person.identifier.ridM-7017-2013
person.identifier.scopus-author-id54973754300
person.identifier.scopus-author-id6603283442
person.identifier.scopus-author-id36841737900
person.identifier.scopus-author-id7005270435
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