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- The role of lipids in drug absorption throught the GITPublication . Doktorovova, Slavomira; Morsy, Tarek; Balcão, Victor; Souto, Eliana B.Os vectores lipídicos apresentam inúmeras vantagens para a administração oral de substâncias farmacológicas, p.ex. são compostos por moléculas lipídicas semelhantes àquelas que figuram nos tecidos humanos, tornando-se biocompatíveis, biotoleráveis e biodegradáveis. São exemplos as tradicionais emulsões O/A, as suspensões de nanopartículas lipídicas (SLNs e NLC s) e, recentemente, as SolEmuls®, que permitem localizar fármacos fracamente solúveis em ambas as fases das emulsões, na camada interfacial de lecitina. Este artigo aborda o papel dos lípidos no aumento da absorção e da biodisponibilidade de fármacos administrados oralmente. Lipid carriers show several advantages for oral delivery of pharmacologically active drugs, e.g. are composed of lipid molecules similar to those in human tissues, becoming therefore biocompatible, biotolerable and biodegradable. Examples include traditional o/w emulsions, suspensions of lipid nanoparticles (SLNs and NLC s) and, recently, the SolEmuls®, which allows localizing poorly soluble drug molecules both in oil and aqueous phases, in the interfacial layer of lecithin. This paper reports on the role of lipids in enhancing both drug absorption and bioavailability when administered orally.
- Development of innovative nanotechnology-based drug delivery systems for cancer therapyPublication . Moutinho, Carla; Matos, Carla; Balcão, VictorControlled drug delivery systems are not a new subject in the biomedical field. The continuously increasing need for the improvement of health care services has been the driving force for both search and development of such systems. Among these, micro- and nano-sized vehicles (e.g. nanocapsules, liposomes and mixed micelles) have received special attention over the last decade; they have been used for the delivery and vectorization of many pharmacologically active molecules, as is the case of anti-neoplastic drugs.
- Lipossomas: vectores atractivos e versáteis para o direccionamento de (bio)fármacosPublication . Conceição, Ana Isabel F. S.; Matos, Carla; Moutinho, Carla; Balcão, VictorOs lipossomas são microsistemas constituídos por uma ou mais bicamadas lipídicas dispostas esfericamente, separadas por fases aquosas, cujo cerne é um compartimento aquoso. Tais estruturas esféricas fechadas, cujo diâmetro varia tipicamente entre os 50 nm e os 5 mm, formam-se espontaneamente quando alguns lípidos são colocados em solução aquosa. Logo após a sua descoberta, na década de sessenta, surgiu a ideia de que poderiam ser usados como transportadores de compostos farmacologicamente activos, dado serem constituídos por compostos naturais, relativamente não-tóxicos e biodegradáveis. Liposomes are microsystems constituted by one or more lipid bilayers, arranged spherically, separated by aqueous phases, with an aqueous core. Such closed spherical structures, typically ranging in diameter from 50 nm to 5 mm, form spontaneously when certain lipids are placed in aqueous solution. Right after their discovery in the sixties, the idea that they could work as carriers for active drugs arose within the scientific community, since they are composed of natural compounds which are relatively non-toxic and biodegradable.