FCS - Número 01 (2004)
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- Hipersensibilidade do sistema imune e patologias da mucosa oralPublication . Barros, Liliana; Ribeiro, SofiaAn overreaction of the immune system to both infectious and inert antigens can lead to severe tissue damage. These hypersensitivity reactions are classified into four main types depending of the response-immediate or delayed and of the immune component involved. In this article we provide some evidences of the role of immunological mechanisms in type I and type IV hypersensitivity trough a relation with oral pathologies known has Contact Stomatitis and Oral Lichen Planus.
- Proteínas dentinogénicas: o material ideal para pulpotomiasPublication . Costa, Maria Esmeralda A. G. Ribeiro daThe pulpotomy technique consists in the extirpation of the coronary pulp and in the placement, in the entrance of the root canals, of a material that protects and preserves the vitality of the remaining pulp in the root. With that purpose, many pulp capping materials have been proposed, as the formocresol, glutaraldehyde, calcium hydroxide and more recently, the morphogenetic proteins. The aim of this work was the study of the action and use of those proteins, capable to induce the dentin formation, while capping agents of pulpar stumps in the pulpotomy.
- Sindrome de sjögren: da imunologia à terapia genéticaPublication . Silva, António Pedro; Felino, Eurico MeloSjögren`s syndrome (SS) is a chronic inflammatory disease with major immunological features that include infiltration of salivary and lacrimal glands by CD4+ T cells and B cells, the presence of autoantibodies to nucleoproteins and its genetic predisposition linked to the HLA region. It`s diagnosis can be made using different criteria approved by WHO. Recent advances in the field of genetic therapy opens new perspectives for the treatment of SS – the use of genes encoding for anti-inflamatory cytokines is being studied.
- Terceira dentição natural, será possível?Publication . Silva, António Pedro; Dias, Nuno Sousa; Cardoso, Inês LopesThe main goal of this work is to present some of the most notorious advances in Dental Medicine, which will probably change greatly the practice of this job. We emphasize the importance of stem cells and molecular biology in the development of dental tissues, teeth in the laboratory and teeth inside the mouth. Some of the research groups involved in these subjects are mentioned, as well as some relevant studies and their future impact in Dentistry.
- Cirurgia oral em doentes hipocoaguladosPublication . Guimarães, JaimeNowadays, there are more dental treatments performed in patients on oral anticoagulant therapy, confronting the Dentist with the necessity to adjust its procedures. Currently, the evaluation of the hipocoagulation state through INR gives us a reliable information and thus, depending on the surgical act, could or could not be necessary to adjust the anticoagulation level of the patient. Antifibrinolitic drugs allows the accomplishment of the surgical intervention with some security, in most cases with the advantage of not being necessary to interrupt the anticoagulant, diminishing the probabilities of occurrence of a tromboembolic accident. Thus, in the presence of a patient on oral anticoagulant therapy, we must get a rigorous information on the anticoagulation levels and, depending on the treatment to carry on, the drug can be continued, allowing the performance of the surgery without major complications, since there are taken some local measures to obtain hemostasis.
- Restaurações de fracturas coronárias de dentes anterioresPublication . Melo, Paulo; Domingues, Joana; Teixeira, Liliana; Manarte-Monteiro, Patricia; Monteiro, BeatrizNowadays crown fractures of anterior teeth are getting more common in children and teenagers. These kinds of accidents can affect them for the rest of them lives, behalf of their age, gender or socioeconomic status. This is one of the reasons why dentists are always trying to find different solutions for the treatment of these cases. Mainly in anterior teeth fractures involving enamel or enamel and dentin, one has the direct restoration solution, using composite resin. In this case, the introduction of the “self-etch” technique, and the evolution of adhesive systems and the better physical and aesthetic behaviour of the composite resins, lead to better results. Thus, one can consider the direct restoration as a valid solution that can be done quickly and still is aesthetic and as an excellent clinical behaviour. The authors present a clinical case of an extended traumatic fracture treated with a micro-hibrid composite resin.
- A dignidade no fim da vidaPublication . Hiller, AdalbertoThe way wich our society faces death, is also the Result of the way wich the same society faces life, because they are together in our way of life. Today, death is each time more distant from the familiar life, and is now a responsibility of the hospital, because nobody wants to have death near. Death is seeing as a failure or a sign from medical incompetence. Our objective is to reflect about the signs of the life we live in direction to death. If life has a sense, perhaps death as a sense too. It is necessary to live life in all her dimension, with all that she brings for us, in a way that death does not means the end, the failure, but the final line. We could appeal to the living people, for them to look for the sense of their lifes, and to live with dignity the fullness of one existence that have right to have the name of life.
- Grandes catástrofesPublication . Pinheiro, M. FátimaMass disasters have always been a subject of interest to the public, as they usually involve a great number of victims. Therefore, each country should carefully evaluate his capacity of response to an event including a considerable number of victims (wounded or dead). In order to achieve this goal, it is essential to create an operational structure and a manual of proceedings with an exhaustive description of the roles of all intervenient parts. Legal Medicine can have a relevant social and humanitarian role. As a matter of fact, it can apply its knowledge to the identification of mortal victims by using traditional methods or/and DNA analysis, when the corpses are severely mutilated.
- Um tratamento postural para a dislexia?Publication . Almeida, Alexandre Frey Pinto deDyslexia is a specific reading disability which requires namely, for a complete diagnosis, the submission to a reading scale and an intelligence scale in the context of an attentive medical and psychological examination. This one is supposed to confirm objectively the reading difficulties and to exclude such possible aetiologies as developmental disturbances of any other nature, sensorial deficit, neurological / psychiatric diseases or main problems in school. Nevertheless, dyslexia often occurs accompanied by dysortography and many neurological “soft-signs”. Pinto de Almeida (1993) also noticed a frequent association with Postural Deficit Syndrome, and this author’s working hypothesis is being supported by new evidence: it seems now to be confirmed that the treatment of the associated PDS by means of postural reprogramming and the use of low potency prismatic lenses may obtain very considerable effects on the reading performance itself. As a matter or fact, G. Serrano and O. Alves da Silva (1998) related very similar results in a great number of dysortographic children, possibly dyslexic ones, arguing that this is the main treatment for most cases, and assuming that the enhancement is due to the correction of proprioceptive dysfunctions caused by vicious positions leading to a cognitive inhibition which could make reading something very hard to do. The author criticises that way of thinking and claims for another conception of dyslexia and even the associated PDS, that could both be seen as “dyslaterality syndromes”, depending on the same general hemispheric function disharmony. Not only this new postural treatment but other performant interventions as well could potenciate each other in order to improve the peculiar neurological background of that syndromatic constellation.
- Caracterização de modelos biomembranares (micelas e lipossomas) para a determinação de coeficientes de partiçãoPublication . Matos, Carla; Moutinho, Carla; Almeida, Cristina; Balcão, VictorA drug´s mechanism of action is dependent and related to its chemical structure and, in the bottom line, to the ability of the structure to interact with biological systems. The phospholipid composed cell membrane is a particularly important system for the pharmacological action of a drug, hence pharmacokinetic parameters are generally related with the drug/membrane interaction. This interaction is dependent on the hydrophilic/lipophilic balance of the drug, a parameter traditionally assessed by the organic solvent/water partition coefficient. Liposomes and micelles, due to their composition and physical organization, can constitute basic structural models for the cell membrane, being a precious tool in drug/membrane interaction studies. The use of these simpler models allows for the comprehension of basic processes, from which a progressive complexity can be added to the system, for a progressive insight of the involved phenomena. In this context, the determination of the liposome/water, or micelle/water partition coefficients, can constitute an indicative parameter of the drug´s real behaviour in the biological system.