Loading...
Publication
Novas abordagens terapêuticas na dermatite atópica
| Name: | Description: | Size: | Format: | |
|---|---|---|---|---|
| 2.11 MB | Adobe PDF |
Authors
Advisor(s)
Abstract(s)
A dermatite atópica é uma doença inflamatória crónica da pele que afeta todas as faixas etárias com maior incidência nas idades mais jovens. É caracterizada pela xerose cutânea, as lesões eczematosas, eritematosas, exsudativas e crostosas com morfologia e distribuição característica. A disfunção da barreira cutânea e do sistema imunitário são os principais fatores que apresentam maior magnitude quando associados à colonização e infeção frequente pela bactéria patogénica Staphylococcos aureus. A prevenção de manifestações clínicas é o principal foco de tratamento da doença e é nesta perspetiva que surge o interesse na utilização de pré e probióticos quer com atuação a nível tópico como a nível intestinal. Estudos preliminares são otimistas para o seu uso mas são necessários estudos adicionais para determinar o efeito completo que os pré ou probióticos têm sobre a pele, indicando que existem desafios consideráveis pela frente, mas também muitas oportunidades.
Na primeira parte deste trabalho é efetuada a descrição da dermatite atópica, das suas características e complicações. Em seguida é apresentada uma revisão relativa à microbiota cutânea e a importância da manutenção de uma microbiota comensal equilibrada e funcional. Depois são apresentados os diversos tratamentos possíveis para a doença e a sua ordem de escolha e por último é explorado o possível uso de pré e probióticos na prevenção e atenuação dos sintomas atópicos com uma revisão bibliográfica a diferentes estudos clínicos e possibilidades futuras para a implementação destas novas terapêuticas na prática clínica.
Atopic dermatitis is a chronic inflammatory skin disease that affects all age groups with the highest incidence at younger ages. Is characterized by cutaneous xerosis, and eczematous, erythematous, exudative, and crusty lesions with characteristic morphology and distribution. The dysfunction of the skin barrier and the immune system are the main factors that present greater magnitude when associated to colonization and frequent infection by the pathogenic bacteria Staphylococcus aureus. The prevention of clinical manifestations is the main focus of treatment of the disease and it is in this perspective that the interest in the use of pre and probiotics appears with either topical or intestinal level performance. Preliminary studies are optimistic for its use, but further studies are needed to determine the full effect that pre or probiotics have on the skin, indicating that there are considerable challenges ahead, but also many opportunities. In the first part of this work the description of atopic dermatitis, its characteristics and complications is made. The following is a review of the cutaneous microbiota and the importance of maintaining a balanced and functional commensal microbiota. Then the different possible treatments for the disease and its order of choice are presented and finally the possible use of pre and probiotics in the prevention and attenuation of the atopic symptoms is explored with a bibliographical revision to different clinical studies and future possibilities for the implementation of these new therapies in clinical practice.
Atopic dermatitis is a chronic inflammatory skin disease that affects all age groups with the highest incidence at younger ages. Is characterized by cutaneous xerosis, and eczematous, erythematous, exudative, and crusty lesions with characteristic morphology and distribution. The dysfunction of the skin barrier and the immune system are the main factors that present greater magnitude when associated to colonization and frequent infection by the pathogenic bacteria Staphylococcus aureus. The prevention of clinical manifestations is the main focus of treatment of the disease and it is in this perspective that the interest in the use of pre and probiotics appears with either topical or intestinal level performance. Preliminary studies are optimistic for its use, but further studies are needed to determine the full effect that pre or probiotics have on the skin, indicating that there are considerable challenges ahead, but also many opportunities. In the first part of this work the description of atopic dermatitis, its characteristics and complications is made. The following is a review of the cutaneous microbiota and the importance of maintaining a balanced and functional commensal microbiota. Then the different possible treatments for the disease and its order of choice are presented and finally the possible use of pre and probiotics in the prevention and attenuation of the atopic symptoms is explored with a bibliographical revision to different clinical studies and future possibilities for the implementation of these new therapies in clinical practice.
Description
Keywords
Dermatite atópica Tratamento Microbiota Prebióticos Probióticos Staphylococcos aureus Atopic dermatitis Treatment Microbiota Prebiotics Probiotics Staphylococcos aureus