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Biofilmes, microbiomas e infeções da pele
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| 1.07 MB | Adobe PDF |
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Abstract(s)
A presente monografia tem como objetivo compreender os conceitos de biofilme e microbioma, e abordar algumas infeções da pele que poderão resultar do desequilíbrio do microbioma. Diferentes zonas da pele apresentam diferentes ecossistemas, sendo assim, habitadas por diferentes microrganismos.
O microbioma representa a comunidade de microrganismos que naturalmente habitam no corpo humano, constituindo assim parte da identidade humana. Trata-se de um ecossistema complexo que reúne bactérias, fungos e vírus que vivem em comensalismo com o hospedeiro em diversos orgãos, incluindo na pele.
A pele é conhecida como o maior orgão do corpo humano e assume grandes responsabilidades, nomeadamente a sua função termorreguladora e protetora. A pele está constantemente exposta a agentes agressores externos e é também aqui que se manifestam muitas respostas do sistema imunológico.
Os biofilmes e microbiomas são, neste momento, tópicos relevantes de estudo. Os biofilmes podem saudáveis ou patogénicos. Os microbiomas contêm células no estado planctónico, no estado séssil e biofilmes. O desequilíbrio do microbioma pode ser manifestado pela presença de biofilmes patogénicos.
É intuito deste trabalho fazer uma revisão da literatura desde 1978 a 2019, privilegiando os conteúdos mais recentes, que permita entender a dinâmica de biofilmes e microbiomas e constatar a influência do desequilíbrio destes nas infeções da pele.
This monograph aims to understand the concepts of biofilm and microbiome and address some skin infections that may result from the imbalance of the microbiome. Different areas of the skin have different ecosystems, thus being inhabited by different microorganisms. The microbiome represents the community of microorganisms that naturally inhabit the human body, thus forming part of the human identity. It is a complex ecosystem that brings together bacteria, fungi and viruses that live in commensalism with the host in various organs, including the skin. The skin is known as the largest organ of the human body and takes on great responsibilities, namely its thermoregulatory and protective function. The skin is constantly exposed to external aggressors and this is also where many immune system responses are manifested. Biofilms and microbiomes are currently relevant topics of study. Biofilms can be healthy or pathogenic. The microbiomes contain cells in planktonic state, sessile state and biofilms. The microbiome imbalance can be manifested by the presence of pathogenic biofilms. The aim of this paper is to review the literature from 1978 to 2019, focusing on the most recent contents, allowing to understand the dynamics of biofilms and microbiomes and to verify the influence of their imbalance on skin infections.
This monograph aims to understand the concepts of biofilm and microbiome and address some skin infections that may result from the imbalance of the microbiome. Different areas of the skin have different ecosystems, thus being inhabited by different microorganisms. The microbiome represents the community of microorganisms that naturally inhabit the human body, thus forming part of the human identity. It is a complex ecosystem that brings together bacteria, fungi and viruses that live in commensalism with the host in various organs, including the skin. The skin is known as the largest organ of the human body and takes on great responsibilities, namely its thermoregulatory and protective function. The skin is constantly exposed to external aggressors and this is also where many immune system responses are manifested. Biofilms and microbiomes are currently relevant topics of study. Biofilms can be healthy or pathogenic. The microbiomes contain cells in planktonic state, sessile state and biofilms. The microbiome imbalance can be manifested by the presence of pathogenic biofilms. The aim of this paper is to review the literature from 1978 to 2019, focusing on the most recent contents, allowing to understand the dynamics of biofilms and microbiomes and to verify the influence of their imbalance on skin infections.
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Keywords
Biofilmes Microbioma Fisiologia da pele Pele Microbioma da pele Infeções da pele Dermatite atópica Dermatite seborreica Bactérias Fungos Vírus Acne Biofilms Microbiome Skin physiology Skin Skin microbiome Skin infections Atopic dermatitis Seborrheic dermatitis Bacteria Fungi Virus Acne