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Publication
Toranja: benefícios e riscos para a saúde
| Name: | Description: | Size: | Format: | |
|---|---|---|---|---|
| TC_29167 | 769.22 KB | Adobe PDF |
Authors
Advisor(s)
Abstract(s)
Interação medicamentosa é um evento clínico em que os efeitos de um fármaco são
alterados pelo uso concomitante ou anterior à administração de outro fármaco, alimento ou
bebida.
A toranja tem vindo a ser estudada pelo potencial da sua utilização no combate de doenças
crónicas devido à sua atividade antioxidante, anti-inflamatória, anticancerígena, bem como
anti aterosclerótica.
No entanto, a toranja é um dos alimentos mais estudados pelo seu potencial de interações
medicamentosas.
Avaliar a importância terapêutica das interações entre os alimentos e os medicamentos é
particularmente difícil, sendo estas interações principalmente de natureza farmacocinética
e muito complexa. Deste modo, a ingestão de alimentos pode influenciar parâmetros como
a absorção, distribuição, metabolização e eliminação de determinados fármacos, ou, por
outro lado, não influenciar estes parâmetros.
A toranja é um exemplo conhecido deste tipo de interações, uma vez que pode interferir
com alguns fármacos e causar toxicidade severa.
A naringina, a naringenina e as furanocumarinas são componentes presentes na toranja e
que são responsáveis pela inibição do CYP3A4 originando assim as interações com os
fármacos.
Sabe-se que inúmeros fármacos interagem com o sumo da toranja. Muitos destes fármacos
são prescritos para o tratamento de doenças comuns e são metabolizados pelo citocromo
P450 3A4.
A glicoproteína-P e os polipéptidos transporte de aniões orgânicos estão também
envolvidos nas interações com os fármacos, uma vez que sofrem interações com os
compostos polifenólicos presentes na toranja.
Com o desenvolvimento deste trabalho, pretende-se estudar as características e as
propriedades da toranja, assim como as interações que existem entre este fruto e os
fármacos e em particular o modo como o perfil farmacocinético dos fármacos é afetado.
Drug interaction is a clinical event in which the effects of a drug are altered by the concomitant, or prior, use of another drug, food or drink. Grapefruit has been used in the fight against chronic diseases due to its anti-oxidant, antiinflammatory, anticancer, as well as anti-atherosclerotic activity. However, grapefruit is also one of the foods most studied for its potential drug interactions. Assessing the therapeutic importance of interactions between food and drugs is particularly difficult, and these interactions are mainly pharmacokinetics and very complex. Thus, food intake can influence parameters such as the absorption, distribution, metabolization and elimination of certain drugs, or, on the other hand, do not influence these parameters. Grapefruit is a known example of such interactions as it may interfere with some drugs and cause severe toxicity. Naringin, naringenin and furanocoumarins are components present in the grapefruit that are responsible for the inhibition of CYP3A4, thus leading to drug interactions. It is known that innumerable drugs interact with grapefruit juice. Many of these drugs are prescribed for the treatment of common diseases and are metabolized by cytochrome P450 3A4. P-gp and OATP are also involved in drug interactions as they undergo interactions with the polyphenolic compounds present in the grapefruit. This work intends to study the characteristics and properties of grapefruit, as well as the interactions between this fruit and drugs, and particularly to understand how the pharmacokinetic profile of the drugs is affected.
Drug interaction is a clinical event in which the effects of a drug are altered by the concomitant, or prior, use of another drug, food or drink. Grapefruit has been used in the fight against chronic diseases due to its anti-oxidant, antiinflammatory, anticancer, as well as anti-atherosclerotic activity. However, grapefruit is also one of the foods most studied for its potential drug interactions. Assessing the therapeutic importance of interactions between food and drugs is particularly difficult, and these interactions are mainly pharmacokinetics and very complex. Thus, food intake can influence parameters such as the absorption, distribution, metabolization and elimination of certain drugs, or, on the other hand, do not influence these parameters. Grapefruit is a known example of such interactions as it may interfere with some drugs and cause severe toxicity. Naringin, naringenin and furanocoumarins are components present in the grapefruit that are responsible for the inhibition of CYP3A4, thus leading to drug interactions. It is known that innumerable drugs interact with grapefruit juice. Many of these drugs are prescribed for the treatment of common diseases and are metabolized by cytochrome P450 3A4. P-gp and OATP are also involved in drug interactions as they undergo interactions with the polyphenolic compounds present in the grapefruit. This work intends to study the characteristics and properties of grapefruit, as well as the interactions between this fruit and drugs, and particularly to understand how the pharmacokinetic profile of the drugs is affected.
Description
Trabalho Complementar apresentado à Universidade Fernando Pessoa como parte dos requisitos para obtenção do grau de licenciado em Ciências da Nutrição
Keywords
Toranja Interação fármaco-toranja Inibição do CYP3A4 Furanocumarinas Grapefruit Drug-grapefruit interaction Inhibition of CYP3A4 Furanocoumarins