Loading...
Publication
Efeito da curcumina na mucosite oral pós radioterapia e quimioterapia: revisão sistemática
| Name: | Description: | Size: | Format: | |
|---|---|---|---|---|
| Projeto de pós-graduação_40931 | 381.28 KB | Adobe PDF |
Authors
Advisor(s)
Abstract(s)
A mucosite oral corresponde à inflamação da membrana mucosa da cavidade oral secundária a tratamentos de radioterapia e/ou quimioterapia sendo as áreas mais afetadas o palato mole, áreas amigdalianas, mucosa oral e labial, língua, parede faríngea e mucosa laríngea. Esta condição pode surgir entre a segunda e a terceira semana do início do tratamento e durar até duas ou três semanas após o fim do tratamento. As intervenções no tratamento da mucosite oral visam principalmente aliviar os sintomas que esta provoca. Neste sentido, a curcumina mostra-se muito promissora como terapia de tratamento não farmacológico para a mucosite oral. Assim, o objetivo desta revisão sistemática é analisar os efeitos benéficos da curcumina na mucosite oral associada à quimioterapia e/ou radioterapia de cancro oral. Para tal, foi realizada uma pesquisa bibliográfica, nas bases de dados online de artigos científicos PubMed, ScienceDirect e Web of Science sendo que a estratégia de pesquisa nas várias plataformas passou pela utilização da seguinte combinação de palavras-chave: (Curcumin AND (oral mucositis) AND (head and neck cancer) AND (radiotherapy OR chemotherapy)). Foram definidos os seguintes critérios de inclusão: Ensaios clínicos incluindo ensaios clínicos randomizados, estudos piloto e estudos comparativos, estudos realizados em humanos, estudos que abordam especificamente os efeitos da curcumina na mucosite oral relacionada a tratamentos oncológicos (quimioterapia ou radioterapia) e artigos nos idiomas português e inglês publicados nos últimos 11 anos (2014-2024). Dos 573 artigos iniciais foram incluídos 10 estudos, sendo estes avaliados quanto ao seu risco de viés pela ferramenta RoB2. Pela análise dos estudos selecionados verificou-se que a curcumina parece ser eficaz, bem tolerada e segura na prevenção e melhoria da mucosite oral induzida por radioterapia / quimioterapia em pacientes com cancro oral. Os resultados para a aplicação oral ou tópica da curcumina são semelhantes, mas dentro da aplicação tópica o gel apresentou melhores resultados com uma recuperação mais rápida e completa, melhor cicatrização e com menos efeitos colaterais. No entanto, ensaios clínicos randomizados de qualidade multicêntricos com formulações inovadoras de curcumina são necessários para apoiar ainda mais as evidências na prevenção e tratamento da mucosite oral. São também necessários mais estudos clínicos para confirmar a dosagem precisa e o tempo de administração da curcumina no tratamento de doentes com esta patologia.
Oral mucositis is the inflammation of the mucous membrane of the oral cavity secondary to radiotherapy and/or chemotherapy treatments, with the most affected areas being the soft palate, tonsillar areas, oral and labial mucosa, tongue, pharyngeal wall and laryngeal mucosa. This condition can appear between the second and third week of starting treatment and last up to two or three weeks after the end of treatment. Interventions in the treatment of oral mucositis mainly aim to alleviate the symptoms it causes. In this sense, curcumin shows great promise as a non-pharmacological treatment therapy for oral mucositis. Therefore, the objective of this systematic review is to analyze the beneficial effects of curcumin in oral mucositis associated with chemotherapy and/or radiotherapy for oral cancer. To this end, a bibliographic search was carried out in the online databases of scientific articles PubMed, ScienceDirect and Web of Science, and the search strategy on the various platforms involved using the following combination of keywords: (Curcumin AND (oral mucositis) AND (head and neck cancer) AND (radiotherapy OR chemotherapy)). The following inclusion criteria were defined: Clinical trials including randomized clinical trials, pilot studies and comparative studies, studies conducted in humans, studies that specifically address the effects of curcumin on oral mucositis related to oncological treatments (chemotherapy or radiotherapy) and articles in Portuguese and English published in the last 11 years (2014-2024). Of the 573 initial articles, 10 studies were included, which were assessed for their risk of bias using the RoB2 tool. The analysis of the selected studies showed that curcumin appears to be effective, well tolerated and safe in the prevention and improvement of oral mucositis induced by radiotherapy/chemotherapy in patients with oral cancer. The results for oral and topical application of curcumin are similar, but within the topical application, the gel showed better results with faster and more complete recovery, better healing and fewer side effects. However, high-quality multicenter randomized clinical trials with innovative curcumin formulations are needed to further support the evidence for the prevention and treatment of oral mucositis. More clinical studies are also needed to confirm the precise dosage and timing of curcumin administration in the treatment of patients with this condition.
Oral mucositis is the inflammation of the mucous membrane of the oral cavity secondary to radiotherapy and/or chemotherapy treatments, with the most affected areas being the soft palate, tonsillar areas, oral and labial mucosa, tongue, pharyngeal wall and laryngeal mucosa. This condition can appear between the second and third week of starting treatment and last up to two or three weeks after the end of treatment. Interventions in the treatment of oral mucositis mainly aim to alleviate the symptoms it causes. In this sense, curcumin shows great promise as a non-pharmacological treatment therapy for oral mucositis. Therefore, the objective of this systematic review is to analyze the beneficial effects of curcumin in oral mucositis associated with chemotherapy and/or radiotherapy for oral cancer. To this end, a bibliographic search was carried out in the online databases of scientific articles PubMed, ScienceDirect and Web of Science, and the search strategy on the various platforms involved using the following combination of keywords: (Curcumin AND (oral mucositis) AND (head and neck cancer) AND (radiotherapy OR chemotherapy)). The following inclusion criteria were defined: Clinical trials including randomized clinical trials, pilot studies and comparative studies, studies conducted in humans, studies that specifically address the effects of curcumin on oral mucositis related to oncological treatments (chemotherapy or radiotherapy) and articles in Portuguese and English published in the last 11 years (2014-2024). Of the 573 initial articles, 10 studies were included, which were assessed for their risk of bias using the RoB2 tool. The analysis of the selected studies showed that curcumin appears to be effective, well tolerated and safe in the prevention and improvement of oral mucositis induced by radiotherapy/chemotherapy in patients with oral cancer. The results for oral and topical application of curcumin are similar, but within the topical application, the gel showed better results with faster and more complete recovery, better healing and fewer side effects. However, high-quality multicenter randomized clinical trials with innovative curcumin formulations are needed to further support the evidence for the prevention and treatment of oral mucositis. More clinical studies are also needed to confirm the precise dosage and timing of curcumin administration in the treatment of patients with this condition.
Description
Keywords
Curcumina Oral mucosite Cancro da cabeça e pescoço Radioterapia Quimioterapia Curcumin Oral mucositis Head and neck cancer Radiotherapy Chemotherapy