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Mediadores pró-resolving e o seu papel na doença periodontal
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Abstract(s)
A periodontite é uma doença oral de etiologia bacteriana e de patogénese inflamatória que afeta os tecidos periodontais e que pode levar a problemas de saúde pelo risco de associação com outras doenças inflamatórias sistémicas.
Os mecanismos envolvidos na resolução da inflamação têm sido alvo das atuais pesquisas na patogénese da doença periodontal porque atenuam a resposta inflamatória e possivelmente regeneram os tecidos periodontais. Mediadores lipídicos pro-resolving endógenos derivados de ômega-3 da dieta estão presentes em células animais e estão relacionados com a regulação inflamatória.
A administração local de análogos destes mediadores em bolsas periodontais, como os derivados do ácido araquidónico, as resolvinas, apresentam-se como potenciais orquestradores da resolução da inflamação e da regeneração dos tecidos perdidos.
O objetivo deste estudo foi analisar as recentes descobertas sobre a relação da periodontite e seus subprodutos na degradação do periodonto e suas implicações sistémicas, identificando perspectivas futuras ao tratamento para a periodontite.
Periodontitis is an oral disease of bacterial etiology and inflammatory pathogenesis that affects periodontal tissues and may lead to health problems due to the risk of association with others systemic inflammatory diseases. The mechanisms involved in resolving inflammation have been the subject of current research into the pathogenesis of periodontal disease because they attenuate the inflammatory response and possibly regenerate periodontal tissues. Endogenous pró-resolving lipid mediators omega-3 derived of dietary are present in animal cells and are related to inflammatory regulation. Local administration of analogues of these mediators in periodontal pockets, such as arachidonic acid derivatives, resolvins, are potential orchestrators for resolving inflammation and regeneration lost tissues. The aim of this study was to analyse recent findings on the relationship of periodontitis and its systemic implications, identifying its products in periodontal degradation and future prospects for treatment for periodontitis.
Periodontitis is an oral disease of bacterial etiology and inflammatory pathogenesis that affects periodontal tissues and may lead to health problems due to the risk of association with others systemic inflammatory diseases. The mechanisms involved in resolving inflammation have been the subject of current research into the pathogenesis of periodontal disease because they attenuate the inflammatory response and possibly regenerate periodontal tissues. Endogenous pró-resolving lipid mediators omega-3 derived of dietary are present in animal cells and are related to inflammatory regulation. Local administration of analogues of these mediators in periodontal pockets, such as arachidonic acid derivatives, resolvins, are potential orchestrators for resolving inflammation and regeneration lost tissues. The aim of this study was to analyse recent findings on the relationship of periodontitis and its systemic implications, identifying its products in periodontal degradation and future prospects for treatment for periodontitis.
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Keywords
Inflamação e periodontite Terapia periodontal e mediadores pro-resolving Regulação da inflamação periodontal Inflamation and periodontitis Periodontal therapeutics and pro-resolving mediators Periodontal inflammatory regulation