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Compressed matrix core tablet as a quick/slow dual-component delivery system containing ibuprofen

2007Journal article Restricted access
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dc.contributor.authorLopes, Carla Martins
dc.contributor.authorLobo, José M. Sousa
dc.contributor.authorPinto, João F.
dc.contributor.authorCosta, Paulo C.
dc.date.accessioned2020-09-28T15:13:40Z
dc.date.available2020-09-28T15:13:40Z
dc.date.issued2007
dc.date.updated2020-07-24T17:33:30Z
dc.description.abstractThe purpose of the present research was to produce a quick/slow biphasic delivery system for ibuprofen. A dualcomponent tablet made of a sustained release tableted core and an immediate release tableted coat was prepared by direct compression. Both the core and the coat contained a model drug (ibuprofen). The sustained release effect was achieved with a polymer (hydroxypropyl methylcellulose [HPMC] or ethylcellulose) to modulate the release of the drug. The in vitro drug release profile from these tablets showed the desired biphasic release behavior: the ibuprofen contained in the fast releasing component was dissolved within 2 minutes, whereas the drug in the core tablet was released at different times (≈16 or 924 hours), depending on the composition of the matrix tablet. Based on the release kinetic parameters calculated, it can be concluded that the HPMC core was suitable for providing a constant and controlled release (zero order) for a long period of time.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.doidoi.org/10.1208/pt0803076pt_PT
dc.identifier.eid2-s2.0-35348839011
dc.identifier.eid2-s2.0-35148838685
dc.identifier.slugcv-prod-337010
dc.identifier.urihttp://hdl.handle.net/10284/9005
dc.language.isoengpt_PT
dc.subjectBiphasic delivery systempt_PT
dc.subjectDual-component tabletpt_PT
dc.titleCompressed matrix core tablet as a quick/slow dual-component delivery system containing ibuprofenpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPageE202pt_PT
oaire.citation.startPageE195pt_PT
oaire.citation.titleAAPS PharmSciTechpt_PT
oaire.citation.volume8pt_PT
person.familyNameLopes
person.givenNameCarla
person.identifier.ciencia-id901D-160C-633E
person.identifier.orcid0000-0001-5080-032X
person.identifier.ridM-4689-2016
person.identifier.scopus-author-id26649517700
rcaap.cv.cienciaid901D-160C-633E | Carla Martins Lopes
rcaap.rightsrestrictedAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublicationd2a48cfe-9258-4916-99be-bbcb710f6605
relation.isAuthorOfPublication.latestForDiscoveryd2a48cfe-9258-4916-99be-bbcb710f6605

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