Compressed matrix core tablet as a quick/slow dual-component delivery system containing ibuprofen

Lopes, Carla Martins; Lobo, José M. Sousa; Pinto, João F.; Costa, Paulo C.

http://hdl.handle.net/10284/9005

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Abstract(s)

The purpose of the present research was to produce a quick/slow biphasic delivery system for ibuprofen. A dualcomponent tablet made of a sustained release tableted core and an immediate release tableted coat was prepared by direct compression. Both the core and the coat contained a model drug (ibuprofen). The sustained release effect was achieved with a polymer (hydroxypropyl methylcellulose [HPMC] or ethylcellulose) to modulate the release of the drug. The in vitro drug release profile from these tablets showed the desired biphasic release behavior: the ibuprofen contained in the fast releasing component was dissolved within 2 minutes, whereas the drug in the core tablet was released at different times (≈16 or 924 hours), depending on the composition of the matrix tablet. Based on the release kinetic parameters calculated, it can be concluded that the HPMC core was suitable for providing a constant and controlled release (zero order) for a long period of time.