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Compressed matrix core tablet as a quick/slow dual-component delivery system containing ibuprofen
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Orientador(es)
Resumo(s)
The purpose of the present research was to produce a
quick/slow biphasic delivery system for ibuprofen. A dualcomponent tablet made of a sustained release tableted core
and an immediate release tableted coat was prepared by
direct compression. Both the core and the coat contained a
model drug (ibuprofen). The sustained release effect was
achieved with a polymer (hydroxypropyl methylcellulose
[HPMC] or ethylcellulose) to modulate the release of the
drug. The in vitro drug release profile from these tablets
showed the desired biphasic release behavior: the ibuprofen
contained in the fast releasing component was dissolved
within 2 minutes, whereas the drug in the core tablet was
released at different times (≈16 or 924 hours), depending on
the composition of the matrix tablet. Based on the release
kinetic parameters calculated, it can be concluded that the
HPMC core was suitable for providing a constant and controlled release (zero order) for a long period of time.
Descrição
Palavras-chave
Biphasic delivery system Dual-component tablet