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A telomerase e a terapĂȘutica do cancro: futuras perspectivas

2008Journal article Open access
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dc.contributor.authorPedrosa, Nunopor
dc.contributor.authorCardoso, InĂȘs Lopes
dc.contributor.authorMachado, Joana Queirozpor
dc.date.accessioned2009-02-12T09:41:56Zpor
dc.date.accessioned2011-10-06T14:52:30Z
dc.date.available2009-02-12T09:41:56Zpor
dc.date.available2011-10-06T14:52:30Z
dc.date.issued2008por
dc.description.abstractOs telĂłmeros localizam-se nas terminaçÔes dos cromossomas, sendo essenciais para a manutenção da sua integridade, prevenindo fusĂ”es terminais. Grande parte das proteĂ­nas com localização nos telĂłmeros foram recentemente identificadas, contudo muitas das suas funçÔes continuam por esclarecer. MutaçÔes em genes codificantes destas proteĂ­nas causam diversas sĂ­ndromes genĂ©ticas raras, caracterizadas por instabilidade genĂ©tica, cromossĂłmica e predisposição para cancro. A compreensĂŁo do funcionamento biolĂłgico do telĂłmero, permitirĂĄ o desenvolvimento de novos mĂ©todos de diagnĂłstico, prevenção e terapĂȘuticas mais eficazes para cada sĂ­ndrome. Telomeres are located at chromosomes ends, having essential roles in preventing terminal fusions. Several telomeric proteins were recently identified, however most of their functions are not yet understood. Mutations at the genes encoding these proteins cause a number of rare genetic syndromes, characterized by genetic and/or chromosome instability and predisposition to cancer. The understanding of the whole mechanism of operation of telomere biology, will enable the development of new methods of diagnosis, prevention and more effective treatment for each syndrome.por
dc.identifier.citationRevista da Faculdade de CiĂȘncias da SaĂșde. Porto. ISSN 1646-0480. 5 (2008) 114-122.por
dc.identifier.issn1646-0480por
dc.identifier.urihttp://hdl.handle.net/10284/937por
dc.language.isoporpor
dc.publisherEdiçÔes Universidade Fernando Pessoapor
dc.relation.ispartofseriesRevista da Faculdade de CiĂȘncias da SaĂșdepor
dc.relation.ispartofseries5por
dc.subjectTelĂłmeropor
dc.subjectTelomerasepor
dc.subjectAtaxia telangiectasiapor
dc.subjectSĂ­ndrome Nijmegen breakagepor
dc.subjectSĂ­ndrome de Bloompor
dc.subjectSĂ­ndrome de Wernerpor
dc.subjectAnemia de Fanconipor
dc.subjectTelomerepor
dc.subjectNijmegen breakage syndromepor
dc.subjectBloom syndromepor
dc.subjectWerner syndromepor
dc.subjectFanconi anaemiapor
dc.titleA telomerase e a terapĂȘutica do cancro: futuras perspectivaspor
dc.typejournal article
dspace.entity.typePublication
person.familyNameLopes Cardoso
person.givenNameInĂȘs
person.identifier.ciencia-idF21F-16B4-3715
person.identifier.orcid0000-0002-0693-9831
person.identifier.ridM-7156-2013
person.identifier.scopus-author-id54973754300
rcaap.rightsopenAccesspor
rcaap.typearticlepor
relation.isAuthorOfPublicationf39fa18f-2d23-4690-bfa2-f8ba53e40775
relation.isAuthorOfPublication.latestForDiscoveryf39fa18f-2d23-4690-bfa2-f8ba53e40775

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FCS - NĂșmero 05 (2008)