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Hyperhomocysteinemia: how does it affect the development of cardiovascular disease?

dc.contributor.authorCardoso, Inês Lopes
dc.date.accessioned2020-03-02T17:03:20Z
dc.date.available2020-03-02T17:03:20Z
dc.date.issued2018
dc.date.updated2020-02-28T16:11:59Z
dc.description.abstractHomocysteine is an amino acid with an SH group, metabolised by the remethylation and transsulfuration pathways. Several genetic and environmental factors (like deficient nutrition status, systemic disease or consumption of certain drugs), can lead to changes in the levels of plasma homocysteine. Nowadays, hyperhomocysteinemia is considered an important and independent risk factor for atherosclerosis and cardiovascular disease. Several pathological mechanisms have been proposed for the effect of hyperhomocysteinemia in the development of cardiovascular disease. Among them are DNA methylation, decreased protein S-nitrosylation, production of reactive oxidative species and decrease in nitric oxide formation. Main strategies being tested for the treatment of this condition involve supplementation of folic acid, vitamins B6, B12 or riboflavin. From these, increased plasma folic acid levels by folate-rich diet or pharmacological supplementation seems to be the most effective.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.slugcv-prod-368727
dc.identifier.urihttp://hdl.handle.net/10284/8592
dc.language.isoengpt_PT
dc.subjectHomocysteinept_PT
dc.subjectCardiovascular diseasept_PT
dc.subjectFolic acidpt_PT
dc.subjectVitamin B6pt_PT
dc.subjectVitamin B12pt_PT
dc.subjectRiboflavinpt_PT
dc.titleHyperhomocysteinemia: how does it affect the development of cardiovascular disease?pt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.conferencePlaceEstados Unidospt_PT
oaire.citation.endPage12pt_PT
oaire.citation.issue1pt_PT
oaire.citation.startPage1pt_PT
oaire.citation.titleInternational Archives of Cardiovascular Diseasespt_PT
oaire.citation.volume2pt_PT
person.familyNameLopes Cardoso
person.givenNameInês
person.identifier.ciencia-idF21F-16B4-3715
person.identifier.orcid0000-0002-0693-9831
person.identifier.ridM-7156-2013
person.identifier.scopus-author-id54973754300
rcaap.cv.cienciaidF21F-16B4-3715 | Maria Inês de Avelar Lopes Cardoso
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublicationf39fa18f-2d23-4690-bfa2-f8ba53e40775
relation.isAuthorOfPublication.latestForDiscoveryf39fa18f-2d23-4690-bfa2-f8ba53e40775

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