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Hyperhomocysteinemia: how does it affect the development of cardiovascular disease?
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Homocysteine is an amino acid with an SH group, metabolised by the remethylation and transsulfuration pathways.
Several genetic and environmental factors (like deficient
nutrition status, systemic disease or consumption of certain
drugs), can lead to changes in the levels of plasma homocysteine.
Nowadays, hyperhomocysteinemia is considered an important and independent risk factor for atherosclerosis and cardiovascular disease.
Several pathological mechanisms have been proposed for
the effect of hyperhomocysteinemia in the development of
cardiovascular disease. Among them are DNA methylation,
decreased protein S-nitrosylation, production of reactive oxidative species and decrease in nitric oxide formation.
Main strategies being tested for the treatment of this condition involve supplementation of folic acid, vitamins B6, B12
or riboflavin. From these, increased plasma folic acid levels by folate-rich diet or pharmacological supplementation
seems to be the most effective.
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Homocysteine Cardiovascular disease Folic acid Vitamin B6 Vitamin B12 Riboflavin