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A influĂȘncia do microbioma humano nas doenças cardiovasculares
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Abstract(s)
HĂĄ quase um sĂ©culo Ă© reconhecido que os seres humanos possuem um variado e denso ecossistema microbiano a que se dĂĄ o nome de microbioma humano, no entanto estamos ainda a começar de entender muitos dos papĂ©is que estes microrganismos desempenham na saĂșde e no desenvolvimento humano.
Os microrganismos presentes no microbioma humano coexistem em harmonia com o seu hospedeiro, mas podem, em determinadas circunstĂąncias, causar doença. Estes fazem parte de um grupo de espĂ©cies que sĂŁo encontradas em diversas ĂĄreas do corpo humano de indivĂduos saudĂĄveis normais, daĂ o microbioma tambĂ©m ser referido como a flora normal ou comensal. O microbioma Ă© muito diverso e a sua composição varia consoante o local do corpo, sendo constituĂdo principalmente por bactĂ©rias que desempenham um papel importante na manutenção de uma vida saudĂĄvel e equilibrada.
Hå uma crescente explicação de que mudanças na composição do microbioma podem promover uma suscetibilidade a longo prazo para o desenvolvimento de doenças cardiovasculares, pois os metabolitos derivados da fermentação dos microrganismos presentes no microbioma são biologicamente ativos, em especial o N-óxido de trimetilamina (TMAO) que é reconhecido como um agente aterogénico.
Assim, a sua associação Ă s doenças cardiovasculares permitirĂĄ compreender melhor a sua patogĂ©nese e tambĂ©m explorar novas abordagens terapĂȘuticas, tornando o microbioma um alvo terapĂȘutico, cada vez mais relevante.
For almost a century it has been recognized that humans possess a varied and dens microbial ecosystem called the human microbiome, yet we are still beginning to understand many of the roles that these microorganisms play in human health and development. The microorganisms present in the human microbiome coexist in harmony with their host but may under certain circumstances cause disease. Those are part of a group of species that are found in several areas of the human body, in normal healthy individuals, hence the microbiome is also referred to as the normal or commensal flora. The microbiome is very diverse and its composition varies according to the body site, being constitutes mainly by bacteria that play an important role in maintaining a healthy and balanced life. There is an increasing explanation that changes in the microbiome composition may promote long-term susceptibility for cardiovascular, because the metabolites form the fermentation of microorganisms present in the microbiome are biologically active, especially the trimethylamine N-oxide (TMAO), which is recognized as an atherogenic agent. Therefore, its association with cardiovascular diseases will allow a better understanding of its pathogenesis and also explore new therapeutic approaches, making the microbiome a therapeutic target, increasingly relevant.
For almost a century it has been recognized that humans possess a varied and dens microbial ecosystem called the human microbiome, yet we are still beginning to understand many of the roles that these microorganisms play in human health and development. The microorganisms present in the human microbiome coexist in harmony with their host but may under certain circumstances cause disease. Those are part of a group of species that are found in several areas of the human body, in normal healthy individuals, hence the microbiome is also referred to as the normal or commensal flora. The microbiome is very diverse and its composition varies according to the body site, being constitutes mainly by bacteria that play an important role in maintaining a healthy and balanced life. There is an increasing explanation that changes in the microbiome composition may promote long-term susceptibility for cardiovascular, because the metabolites form the fermentation of microorganisms present in the microbiome are biologically active, especially the trimethylamine N-oxide (TMAO), which is recognized as an atherogenic agent. Therefore, its association with cardiovascular diseases will allow a better understanding of its pathogenesis and also explore new therapeutic approaches, making the microbiome a therapeutic target, increasingly relevant.
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Keywords
Microbioma humano Doenças cardiovasculares N-óxido de trimetilamina Aterosclerose Hipertensão Probióticos e prebióticos Human microbiome Cardiovascular diseases Trimethylamine N-oxide Atherosclerosis Hypertension Probiotics and prebiotics