Publication
Nanossistemas lipídicos para a administração de fármacos do nariz para o cérebro no tratamento de tumores cerebrais
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Advisor(s)
Abstract(s)
Os tumores cerebrais afetam grande parte da população e, geralmente, apresentam um mau prognóstico, dependendo da gravidade da condição. As opções de tratamento são limitadas, devido à dificuldade de acesso dos fármacos ao cérebro, visto que existem várias barreiras físicas e fisiológicas, sendo a principal a barreira hematoencefálica (BHE).
Apesar de todos os meios atualmente disponíveis para o tratamento de tumores cerebrais, a qualidade de vida dos doentes é limitada, devido aos efeitos secundários graves, daí que haja necessidade de desenvolver novas formulações que permitam direcionar os fármacos para o cérebro. Neste contexto, surgem os nanossistemas lipídicos para promover o transporte dos fármacos e é explorada a via de administração intranasal como estratégia alternativa de transporte dos fármacos diretamente do nariz para o cérebro, evitando a necessidade de atravessar a BHE. Vários nanossistemas lipídicos intranasais têm sido estudados para o tratamento de gliomas e encontram-se em desenvolvimento pré-clínico, tendo vindo a apresentar resultados promissores, o que aumenta a expectativa em relação ao seu potencial uso clínico.
Brain tumors affect a large part of population and generally have a poor prognosis, depending on the severity of the condition. Treatment options are limited due to the difficulty of drugs accessing the brain, as there are several physical and physiological barriers, mainly the blood-brain barrier (BBB). Even with all the currently available means for treating brain tumors, the quality of life of patients is limited due to the serious side effects, hence the need to develop new formulations that allow drugs to target the brain. In this context lipid nanosystems emerge as a possibility for drug administration and nose-to-brain delivery is explored as an alternative for direct drug administration from the nose to the brain avoiding the need to cross the BBB. Several lipid nanosystems for intranasal administration haves been studied for glioma treatment and are in pre-clinical development, although they have been showing promising results, which raises expectations regarding their potential clinical use.
Brain tumors affect a large part of population and generally have a poor prognosis, depending on the severity of the condition. Treatment options are limited due to the difficulty of drugs accessing the brain, as there are several physical and physiological barriers, mainly the blood-brain barrier (BBB). Even with all the currently available means for treating brain tumors, the quality of life of patients is limited due to the serious side effects, hence the need to develop new formulations that allow drugs to target the brain. In this context lipid nanosystems emerge as a possibility for drug administration and nose-to-brain delivery is explored as an alternative for direct drug administration from the nose to the brain avoiding the need to cross the BBB. Several lipid nanosystems for intranasal administration haves been studied for glioma treatment and are in pre-clinical development, although they have been showing promising results, which raises expectations regarding their potential clinical use.