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Complexação da curcumina com ciclodextrinas
| Name: | Description: | Size: | Format: | |
|---|---|---|---|---|
| PPG_29617 | 1.15 MB | Adobe PDF |
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Advisor(s)
Abstract(s)
A curcumina (Cur) é um composto muitas vezes procurado quer para fins culinários quer para fins terapêuticos, como são exemplo as suas características anti-inflamatorias, antioxidantes, cicatrizantes, antimicrobiana e centrando-se nos últimos anos nas suas propriedades anticancerígenas. No entanto, dentro das suas características físico-químicas a sua lipofilia reduz largamente a sua biodisponibilidade oral comprometendo a atividade terapêutica. Torna-se desta forma necessário desenvolver estratégias para procurar obter um melhor potencial terapêutico da Cur, sendo que estas e outras estratégias fazem aumentar a sua biodisponibilidade, tentando fazer chegar mais concentração do composto à corrente sanguínea/local de ação.
As ciclodextrinas (CDs) são uma boa alternativa para ultrapassar este problema, uma vez que apresentam uma vasta utilização em formulações farmacêuticas devido às suas características anfifílicas, que permitem melhorar a solubilidade de compostos hidrófobos, assim como de compostos hidrófilos, melhorando a sua estabilidade.
Nesta revisão bibliográfica, foram feitas várias pesquisas para avaliar a eficácia da complexação da Cur com CDs. Os resultados indicaram que esta pode realmente ser uma alternativa para ultrapassar a sua baixa solubilidade mas também para usufruir das suas qualidades terapêuticas, maximizando a sua ação no órgão alvo. Foi analisada a afinidade da Cur para diferentes CDs, e verificou-se que há diferenças e que a CD utilizada no complexo também deve ser escolhida conforme a ação pretendida.
Curcumin (Cur) is a compound often presenting both culinary and therapeutic purposes, such as its anti-inflammatory, antioxidant, wound healing, antimicrobial and anti-cancer properties in recent years. However, within its physico-chemical characteristics its lipophilicity greatly reduces its oral bioavailability by imparing the therapeutic activity. It is therefore necessary to develop strategies to seek a better therapeutic potential of curcumin, and other strategies to increase their bioavailability, promoting concentration of the compound into the bloodstream / site of action. Cyclodextrins (CDs) are a good alternative to overcome this problem, since they are widely used in pharmaceutical formulations because of their amphiphilic characteristics, which allow to improve the solubility of hydrophobic compounds as well as hydrophilic compounds, improving their stability. In this literature review, several studies were carried out to evaluate the efficacy of Cur complexation with CDs. The results indicated that this may actually be a solution to overcome its low solubility but also to enjoy its therapeutic qualities, maximizing its action in the target organ. It was also analyzed the affinity of Cur for different CDs, and it was verified that there are differences and that the CD used in the complex should also be chosen according to the intended action.
Curcumin (Cur) is a compound often presenting both culinary and therapeutic purposes, such as its anti-inflammatory, antioxidant, wound healing, antimicrobial and anti-cancer properties in recent years. However, within its physico-chemical characteristics its lipophilicity greatly reduces its oral bioavailability by imparing the therapeutic activity. It is therefore necessary to develop strategies to seek a better therapeutic potential of curcumin, and other strategies to increase their bioavailability, promoting concentration of the compound into the bloodstream / site of action. Cyclodextrins (CDs) are a good alternative to overcome this problem, since they are widely used in pharmaceutical formulations because of their amphiphilic characteristics, which allow to improve the solubility of hydrophobic compounds as well as hydrophilic compounds, improving their stability. In this literature review, several studies were carried out to evaluate the efficacy of Cur complexation with CDs. The results indicated that this may actually be a solution to overcome its low solubility but also to enjoy its therapeutic qualities, maximizing its action in the target organ. It was also analyzed the affinity of Cur for different CDs, and it was verified that there are differences and that the CD used in the complex should also be chosen according to the intended action.
Description
Keywords
Curcumina Ciclodextrinas Complexos de inclusão Biodisponibilidade Curcumin Cyclodextrins Inclusion complexes Bioavailability