Loading...
Publication
Remédios do mar: a importância das propriedades antineoplásicas das esponjas marinhas
| Name: | Description: | Size: | Format: | |
|---|---|---|---|---|
| PPG_26117 | 1.02 MB | Adobe PDF |
Advisor(s)
Abstract(s)
Desde há milhares de anos, que o ser humano tira partido da capacidade da natureza para produzir fármacos. A indústria farmacêutica tem particular interesse nos ecossistemas marinhos como fonte de compostos com reconhecidas propriedades biológicas oriundos de organismos de vários níveis taxonómicos. Devido à sua diversidade química, as esponjas marinhas estão entre os organismos mais promissores para a obtenção de compostos bioativos antineoplásicos. Embora se tenham feito grandes progressos na área da investigação oncológica, o cancro ainda provoca alta mortalidade. A investigação continuada, numa área de intervenção como o cancro, é inquestionavelmente necessária. Este trabalho consistiu numa revisão bibliográfica atual sobre o tema “Remédios do mar: a importância das propriedades antineoplásicas das esponjas marinhas”. Nesta dissertação foram também abordados alguns aspetos históricos da utilização dos organismos marinhos e as suas utilizações farmacológicas ao longo da evolução do ser humano, com especial incidência nas esponjas do mar, como organismos marinhos principais para o tratamento do cancro. Presentemente, a Citarabina (Ara-C) e o Mesilato de eribulina (E7389) são aplicados no tratamento de neoplasias, particularmente no tratamento de leucemias e cancro da mana metastática, respetivamente. Contudo, são observados outros compostos em fase de estudos clínicos, como o Discodermolídeo, Hemiasterlina HTI-286, Hemisaterlina E7974, o PM-060184 e Panobinostat e outros em fase de estudo pré-clínico, Spongistatina e o Laulimalìdeo.
Estes estudos dão uma esperança acrescida aos doentes oncológicos e são um passo importante na cura do cancro.
For thousands of years, humans have taken advantage of nature's ability to produce drugs. The pharmaceutical industry has a particular interest in marine ecosystems as a source of compounds with recognized biological properties from organisms of various taxonomic levels. Due to their chemical diversity, the marine sponges are among the most promising organisms for obtaining antineoplastic bioactive compounds. Although a great progress has been made in oncological research, cancer is still one of the causes for human high mortality. High quality research in an area of intervention such as cancer is unquestionably necessary. This study consists of a current bibliographical review about the theme "Drugs from the sea: the importance of the antineoplastic properties of the marine sponges ". This dissertation was also addressed some historical aspects of the use of marine organisms and their pharmacological uses throughout human evolution, with special emphasis on sea sponges as the main marine organisms for the cancer treatment. At present, Cytarabine (Ara-C) and eribulin mesylate (E7389) are applied in the treatment of neoplasms, particularly in the treatment of leukemia’s and metastatic breast cancer, respectively. However, other compounds in the clinical study stage, such as Discodermolide, Hemiasterlina HTI-286, Hemisaterlina E7974, PM-060184 and Panobinostat and others in the preclinical study phase, Spongistatin and Laulimalide are observed. These studies increased hope to cancer patients and are an important step in curing cancer.
For thousands of years, humans have taken advantage of nature's ability to produce drugs. The pharmaceutical industry has a particular interest in marine ecosystems as a source of compounds with recognized biological properties from organisms of various taxonomic levels. Due to their chemical diversity, the marine sponges are among the most promising organisms for obtaining antineoplastic bioactive compounds. Although a great progress has been made in oncological research, cancer is still one of the causes for human high mortality. High quality research in an area of intervention such as cancer is unquestionably necessary. This study consists of a current bibliographical review about the theme "Drugs from the sea: the importance of the antineoplastic properties of the marine sponges ". This dissertation was also addressed some historical aspects of the use of marine organisms and their pharmacological uses throughout human evolution, with special emphasis on sea sponges as the main marine organisms for the cancer treatment. At present, Cytarabine (Ara-C) and eribulin mesylate (E7389) are applied in the treatment of neoplasms, particularly in the treatment of leukemia’s and metastatic breast cancer, respectively. However, other compounds in the clinical study stage, such as Discodermolide, Hemiasterlina HTI-286, Hemisaterlina E7974, PM-060184 and Panobinostat and others in the preclinical study phase, Spongistatin and Laulimalide are observed. These studies increased hope to cancer patients and are an important step in curing cancer.
Description
Keywords
Organismos marinhos Filo porifera Farmacopeia Cancro Antitumorais Marine organisms Phylum porifera Pharmacopoeia Cancer Antitumour