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Publication
Papel das ceramidas na fisiopatologia da pele
| Name: | Description: | Size: | Format: | |
|---|---|---|---|---|
| PPG_26427 | 1.33 MB | Adobe PDF |
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Abstract(s)
Os esfingolípidos representam uma classe estruturalmente heterogénea de moléculas lípidicas tipicamente observada nas membranas de células eucarióticas. Para além da sua função estrutural nas biomembranas, os esfingolípidos participam numa complexa rede de reações que abrangem várias vias metabólicas (anabólica, catabólica, reciclagem e ciclo da esfingomielina) e desempenham funções de regulação em eventos celulares muito diversos, tais como a proliferação, inflamação ou apoptose celular. Deste ponto de vista, a ceramida ocupa uma posição central no metabolismo dos esfingolípidos e é uma molécula lípidica funcionalmente multifacetada. Estas características justificam a associação da ceramida com a patogénese de doenças clinicamente distintas, designadamente as doenças crónicas da pele. Estas doenças são, geralmente, caracterizadas por uma inter-relação complexa entre vários fatores etiopatogénicos, incluindo alterações em etapas específicas do metabolismo da ceramida. Por isso, estratégias terapêuticas de reposição do nível de equilíbrio da ceramida e/ou metabolitos relacionados têm suscitado um grande interesse e revelado resultados promissores. Contudo, a diversidade estrutural das ceramidas, bem como dos seus derivados metabólicos, colocam muitos desafios e oportunidades que deverão continuar a ser investigados, no futuro. O presente trabalho de revisão analisa, assim, a estrutura, a função e o metabolismo dos esfingolípidos, bem como a sua relação com a fisiopatologia da pele e com estratégias terapêuticas representativas de potenciais tratamentos de primeira linha das doenças crónicas da pele.
The sphingolipids represent a structurally heterogeneous class of lipid molecules typically observed in eukaryotic cell membranes. In addition to its structural role in biomembranes, the sphingolipids participate in a complex network of reactions encompassing various metabolic pathways (anabolic, catabolic, cycling and sphingomyelin cycle) and play regulatory roles in very diverse cellular events such as proliferation, inflammation or cell apoptosis. From this point of view, the ceramide occupies a central position in the sphingolipid metabolism and is a functionally multifaceted lipid molecule. These characteristics justify the association of ceramide with the pathogenesis of clinically distinct diseases, namely chronic skin diseases. These diseases are usually characterised by a complex interrelationship between different etiopathogenic factors, including alterations in specific steps of the ceramide metabolism. Therefore, therapeutic strategies to restore a balanced level of ceramide and/or related metabolites have aroused great interest and revealed promising results. However, the structural diversity of ceramides, as well as its metabolic derivatives, poses many challenges and opportunities that should continue to be investigated in the future. The present review thus analyses the structure, function and metabolism of sphingolipids, as well as its relation with skin pathophysiology and therapeutic strategies representing potential first line treatments for these chronic skin diseases.
The sphingolipids represent a structurally heterogeneous class of lipid molecules typically observed in eukaryotic cell membranes. In addition to its structural role in biomembranes, the sphingolipids participate in a complex network of reactions encompassing various metabolic pathways (anabolic, catabolic, cycling and sphingomyelin cycle) and play regulatory roles in very diverse cellular events such as proliferation, inflammation or cell apoptosis. From this point of view, the ceramide occupies a central position in the sphingolipid metabolism and is a functionally multifaceted lipid molecule. These characteristics justify the association of ceramide with the pathogenesis of clinically distinct diseases, namely chronic skin diseases. These diseases are usually characterised by a complex interrelationship between different etiopathogenic factors, including alterations in specific steps of the ceramide metabolism. Therefore, therapeutic strategies to restore a balanced level of ceramide and/or related metabolites have aroused great interest and revealed promising results. However, the structural diversity of ceramides, as well as its metabolic derivatives, poses many challenges and opportunities that should continue to be investigated in the future. The present review thus analyses the structure, function and metabolism of sphingolipids, as well as its relation with skin pathophysiology and therapeutic strategies representing potential first line treatments for these chronic skin diseases.
Description
Keywords
Ceramidas Dermatite atópica Doenças crónicas de pele Esfingolípidos Metabolismo Psoríase Atopic dermatitis Ceramide Chronic skin diseases Metabolism Psoriasis Sphingolipids