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Esclerose mĂșltipla: abordagem geral e terapĂȘuticas atuais
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| PPG_25673 | 1003.2 KB | Adobe PDF |
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Abstract(s)
A Esclerose MĂșltipla (EM) Ă© uma doença crĂłnica autoimune, que atinge a bainha de mielina causando a sua degeneração. Ă uma doença inflamatĂłria do sistema nervoso central (SNC), e a causa mais comum de incapacidade em jovens adultos, sendo complexa e de origem multifatorial.
A sua incidĂȘncia varia entre gĂ©neros, populaçÔes e distribuição geogrĂĄfica, e Ă© mais frequente em idades entre 20-40 anos, sendo pouco frequente em crianças e rara em idosos.
Ă uma doença que tem revelado especial interesse uma vez que, quer no seu diagnĂłstico, quer no tratamento permaneçam ainda desafios para a comunidade mĂ©dica e vĂĄrios novos fĂĄrmacos tĂȘm sido gradualmente, e de forma crescente, aprovados. No entanto, nĂŁo existe ainda uma cura para EM.
Ă uma doença que resulta num elevado consumo de recursos de saĂșde e implica custos bastante significativos, estimando-se que, sĂł nos Estados Unidos a doença tenha um custo anual de 6,8 biliĂ”es de dĂłlares.
Atualmente existem vĂĄrias opçÔes de tratamento novas, incluindo vĂĄrios fĂĄrmacos de administração oral, evitando assim autoinjecçÔes e internamento para medicação intravenosa. Apesar de a cura parecer ainda um pouco distante, espera-se que futuramente seja possĂvel a administração de fĂĄrmacos com capacidade de reestabelecer a bainha da mielina afetada e permitir uma melhor qualidade de vida aos portadores de EM.
Multiple sclerosis (MS) is a chronic autoimmune disease that affects the myelin sheath causing its degeneration. Itâs an inflammatory central nervous system (CNS) disease, and is the most common cause of disability in young adults, with a complex and multifactorial cause. Its incidence varies between gender, population and geographical distribution, and its more common in ages between 20-40 years, non-frequent in children and rare in the elderly. It is a disease that shows a special relevance, because in the diagnosis and treatment still remain challenges for the medical community and several new drugs have been gradually and increasingly, approved. However, there is still no cure for MS. ItÂŽs a disease that results in high consume of health resources and entails very significant costs, and it is estimated that only in the United States the disease has an annual cost of 6.8 billion dollars. Currently there are several new treatment options, including various oral drugs that avoid self-injections and hospital admittance for intravenous medication. Although the cure seems a little far, it is expected that in the future can be possible to administrate drugs with the ability to restore the myelin sheath affected and allow a better quality of life for patients with MS.
Multiple sclerosis (MS) is a chronic autoimmune disease that affects the myelin sheath causing its degeneration. Itâs an inflammatory central nervous system (CNS) disease, and is the most common cause of disability in young adults, with a complex and multifactorial cause. Its incidence varies between gender, population and geographical distribution, and its more common in ages between 20-40 years, non-frequent in children and rare in the elderly. It is a disease that shows a special relevance, because in the diagnosis and treatment still remain challenges for the medical community and several new drugs have been gradually and increasingly, approved. However, there is still no cure for MS. ItÂŽs a disease that results in high consume of health resources and entails very significant costs, and it is estimated that only in the United States the disease has an annual cost of 6.8 billion dollars. Currently there are several new treatment options, including various oral drugs that avoid self-injections and hospital admittance for intravenous medication. Although the cure seems a little far, it is expected that in the future can be possible to administrate drugs with the ability to restore the myelin sheath affected and allow a better quality of life for patients with MS.
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Keywords
Esclerose mĂșltipla Autoimune IncidĂȘncia DiagnĂłstico Tratamento Multiple sclerosis Autoimmune Incidence Diagnosis Treatment