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A saúde oral é cada vez mais reconhecida como um fator importante na saúde geral, particularmente em relação ao declínio cognitivo e às doenças neurodegenerativas, como a doença de Alzheimer. Esta revisão sistemática tem como objetivo explorar a relação entre a periodontite crónica, a infeção pelo vírus Herpes Simplex tipo 1 (HSV-1) e o risco de desenvolver doença cognitiva em pessoas com 65 anos ou mais. Para tal, foram selecionados oito estudos clínicos obtidos a partir das bases de dados PubMed e ScienceDirect, cumprindo critérios de inclusão e exclusão. Os resultados relatados nesses estudos sugerem que a inflamação crónica ligada à saúde oral, bem como as infecções virais persistentes, podem contribuir para a deterioração cognitiva. Por outro lado, certas intervenções, como o tratamento da periodontite ou a utilização de fármacos antivirais, poderão ter um efeito protetor contra a progressão destas patologias. Estas observações abrem caminho para novas investigações e realçam a importância de um tratamento abrangente que combine a saúde oral e a neurologia.
Oral health is increasingly recognized as an important factor in general health, particularly in relation to cognitive decline and neurodegenerative diseases such as Alzheimer's disease. This systematic review aims to explore the relationship between chronic periodontitis, Herpes Simplex Virus type 1 (HSV-1) infection and the risk of developing cognitive impairment in people aged 65 and over. To this end, eight clinical studies were selected from the PubMed and ScienceDirect databases, meeting inclusion and exclusion criteria. The results reported in these studies suggest that chronic inflammation linked to oral health, as well as persistent viral infections, can contribute to cognitive deterioration. On the other hand, certain interventions, such as the treatment of periodontitis or the use of antiviral drugs, may have a protective effect against the progression of these pathologies. These observations pave the way for further research and highlight the importance of comprehensive treatment combining oral health and neurology.
Oral health is increasingly recognized as an important factor in general health, particularly in relation to cognitive decline and neurodegenerative diseases such as Alzheimer's disease. This systematic review aims to explore the relationship between chronic periodontitis, Herpes Simplex Virus type 1 (HSV-1) infection and the risk of developing cognitive impairment in people aged 65 and over. To this end, eight clinical studies were selected from the PubMed and ScienceDirect databases, meeting inclusion and exclusion criteria. The results reported in these studies suggest that chronic inflammation linked to oral health, as well as persistent viral infections, can contribute to cognitive deterioration. On the other hand, certain interventions, such as the treatment of periodontitis or the use of antiviral drugs, may have a protective effect against the progression of these pathologies. These observations pave the way for further research and highlight the importance of comprehensive treatment combining oral health and neurology.
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Palavras-chave
Doença neurodegenerativa Doença de Alzheimer Deficiência cognitiva Periodontite Saúde oral Vírus do Herpes Simplex Neurodegenerative disease Alzheimer’s disease Cognitive impairment Periodontitis Oral health Herpes Simplex Virus