A carregar...
Publicação
Análise proteómica da saliva como indicador precoce no diagnóstico, severidade e progressão da síndrome de sjogren: uma revisão sistemática
| Nome: | Descrição: | Tamanho: | Formato: | |
|---|---|---|---|---|
| Projeto de pós-graduação_41285 | 1.46 MB | Adobe PDF |
Orientador(es)
Resumo(s)
A Síndrome de Sjogren é uma doença autoimune sistémica crónica que afeta preferencialmente as glândulas exócrinas, levando à sua disfunção progressiva. Esta condição manifesta-se clinicamente, de forma predominante, por sintomas de xeroftalmia e xerostomia, resultantes da infiltração linfocitária e destruição glandular. O diagnóstico precoce é frequentemente dificultado pela inespecificidade clínica inicial e pela sobreposição com outras condições autoimunes. Esta revisão sistemática tem como principal objetivo analisar o papel da saliva como ferramenta complementar no diagnóstico, monitorização da severidade e avaliação da progressão da Síndrome de Sjogren, respondendo à seguinte questão: “A análise salivar pode contribuir de forma eficaz para o diagnóstico, avaliação da severidade e progressão da Sindrome de Sjogren?”. Para isso, foi realizada uma pesquisa bibliográfica nas bases de dados PubMed e ScienceDirect. Foram utilizadas combinações de palavras chave MeSH com os operadores booleanos “AND” e “OR”: “saliva”, “Sjogren’s Syndorme”, “Diagnosis” e “Biomarkers”. Foram incluídos estudos que analisaram quantitativamente e qualitativamente a saliva de pacientes com diagnóstico confirmado de Sindrome de Sjogren. Dos 122 artigos inicialmente identificados, 27 estudos cumpriram os critérios de inclusão. Verificou-se alterações significativas no perfil proteómico da saliva de doentes com Sindrome de Sjogren primário, refletindo perturbações imunológicas, inflamação local e disfunção glandular. Desta forma, a análise salivar revela-se uma ferramenta não invasiva e promissora na prática clínica, contribuindo para o dignóstico mais preciso e acompanhamento individualizado da Síndrome de Sjogren.
Sjogren's Syndrome is a chronic systemic autoimmune disease that primarily affects the exocrine glands, leading to their progressive dysfunction. Clinically, this condition predominantly manifests with symptoms of xerophthalmia and xerostomia, resulting from lymphocytic infiltration and glandular destruction. Early diagnosis is often hindered by the initial clinical nonspecificity clinical presentation and by the overlap with other autoimmune conditions. This systematic review aims to analyse the role of saliva as a complementary tool in the diagnosis, severity monitoring, and progression assessment of Sjogren's Syndrome, addressing the following question: “Can salivary analysis effectively contribute to the diagnosis, severity evaluation and progression of Sjogren's Syndrome?”. To answer this, a bibliographic search was conducted in the PubMed and SciencDirect databases. Combinations of MeSH keywords with the Boolean operators “AND” and “OR” were used: “saliva”, “Sjogren’s Syndorme”, “Diagnosis”, and “Biomarkers”. Studies that quantitatively and qualitatively analyzed the saliva of patients with a confirmed diagnosis of Sjogren's Syndrome were included. Of the 122 articles initially identified, 27 studies met the inclusion criteria. Significant changes were observed in the salivary proteomic profile of patients with primary Sjogren’s syndrome, reflecting immunological disturbances, local inflammation, and glandular dysfunction. Thus,salivary analysis provesto be a non-invasive and promising tool in clinical practice, contributing to a more accurate diagnosis and individualized follow-up of Sjogren's Syndrome.
Sjogren's Syndrome is a chronic systemic autoimmune disease that primarily affects the exocrine glands, leading to their progressive dysfunction. Clinically, this condition predominantly manifests with symptoms of xerophthalmia and xerostomia, resulting from lymphocytic infiltration and glandular destruction. Early diagnosis is often hindered by the initial clinical nonspecificity clinical presentation and by the overlap with other autoimmune conditions. This systematic review aims to analyse the role of saliva as a complementary tool in the diagnosis, severity monitoring, and progression assessment of Sjogren's Syndrome, addressing the following question: “Can salivary analysis effectively contribute to the diagnosis, severity evaluation and progression of Sjogren's Syndrome?”. To answer this, a bibliographic search was conducted in the PubMed and SciencDirect databases. Combinations of MeSH keywords with the Boolean operators “AND” and “OR” were used: “saliva”, “Sjogren’s Syndorme”, “Diagnosis”, and “Biomarkers”. Studies that quantitatively and qualitatively analyzed the saliva of patients with a confirmed diagnosis of Sjogren's Syndrome were included. Of the 122 articles initially identified, 27 studies met the inclusion criteria. Significant changes were observed in the salivary proteomic profile of patients with primary Sjogren’s syndrome, reflecting immunological disturbances, local inflammation, and glandular dysfunction. Thus,salivary analysis provesto be a non-invasive and promising tool in clinical practice, contributing to a more accurate diagnosis and individualized follow-up of Sjogren's Syndrome.
Descrição
Palavras-chave
Síndrome de Sjogren Saliva Biomarcadores salivares Proteómica Beta 2-microglobulina Sjogren's syndrome Saliva biomarkers Proteomics Beta 2- microglobulin