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A transformação de plantas, máquinas do futuro
| Name: | Description: | Size: | Format: | |
|---|---|---|---|---|
| PPG_24367 | 979.35 KB | Adobe PDF |
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Abstract(s)
Atualmente, as proteínas utilizadas pela indústria farmacêutica são produzidas, principalmente, em células de mamíferos, insetos e bactérias. Estes sistemas de produção são eficazes, mas o processo de purificação da proteína produzida é caro, tornando-os inacessíveis a muitos países. Por conseguinte, nos últimos anos, a utilização de plantas como biofábricas tem vindo a ganhar bastante importância. Oferece um sistema escalável, elevada produção de proteínas funcionais, livres dos patógenos próprios dos animais, fáceis de purificar e com um baixo custo no processo de produção e purificação. A rentabilidade da agricultura molecular depende da expressão transitória de genes e da utilização de vetores virais desconstruídos. Contudo, estudam-se novas ferramentas e procedimentos que permitam a produção rentável, com um investimento mínimo.
Currently, the proteins used by the pharmaceutical industry are produced mainly in mammalian cells, insects and bacteria. These production systems are effective, but the process of purification of the protein produced is expensive, making them inaccessible to many countries. Therefore, in recent years, the use of plants as biofactories has gained great importance. Provides a scalable system, high production of functional proteins themselves free from pathogens of animals, easy to purify and at a low cost in the production process and purification. The yield of molecular farming depends on transient gene expression and use of viral vectors deconstructed. However, they study new tools and procedures to allow profitable production, with a minimum investment.
Currently, the proteins used by the pharmaceutical industry are produced mainly in mammalian cells, insects and bacteria. These production systems are effective, but the process of purification of the protein produced is expensive, making them inaccessible to many countries. Therefore, in recent years, the use of plants as biofactories has gained great importance. Provides a scalable system, high production of functional proteins themselves free from pathogens of animals, easy to purify and at a low cost in the production process and purification. The yield of molecular farming depends on transient gene expression and use of viral vectors deconstructed. However, they study new tools and procedures to allow profitable production, with a minimum investment.
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Keywords
Agricultura molecular das plantas Biotecnologia Engenharia genética Plantas transformadas geneticamente Plant molecular farming Biotechnology Genetic engineering Genetically transformed plants