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A associação entre periodontite e aterosclerose: revisão integrativa
| Name: | Description: | Size: | Format: | |
|---|---|---|---|---|
| Projeto de pós-graduação_38253 | 4.26 MB | Adobe PDF |
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Abstract(s)
A periodontite é uma doença inflamatória que afeta os tecidos de suporte dos dentes, causada principalmente por bactérias Gram-negativas que aderem às superfícies dos dentes e são organizadas numa estrutura complexa, a placa bacteriana. Uma condição sine qua non para que ocorra a manifestação clínica desta patologia é a presença de um ou mais patógenos periodontais de um tipo específico e em quantidade suficiente que pertencem principalmente ao complexo vermelho. Vários estudos clínicos e experimentais destacaram a presença de uma forte associação entre doenças periodontais e algumas doenças sistémicas, sendo que a hipótese de que as doenças periodontais possam ter efeitos sistémicos diretos (através da disseminação de bactérias patogénicas) e indiretos (através da sua contribuição para a inflamação sistémica) representa a base teórica para compreender e estudar a relação entre periodontite e outras doenças. Uma das principais patologias relacionadas à cavidade oral e à periodontite é a patologia cardiovascular, sendo que as correlações entre as duas patologias dizem respeito principalmente à aterosclerose. O objetivo desta revisão integrativa é perceber a associação entre a periodontite e a aterosclerose, fatores e mecanismos através dos quais pode existir relação. Para isso foi efetuada uma pesquisa bibliográfica nas bases de dados PubMed e B-On, seguindo as guidelines do fluxograma PRISMA e estratégia PICO e definindo critérios de inclusão e exclusão. Desta pesquisa resultaram 12 artigos que foram englobados na revisão integrativa. Os resultados obtidos pelos vários estudos estabelecem uma ligação entre a doença periodontal e a aterosclerose, sendo que estas duas patologias têm fatores de risco em comum. No entanto, os mecanismos que relacionam ambas ainda necessitam de investigações futuras. São necessários mais estudos longitudinais, segundo classificações de doença periodontal mais específicas e com um controlo de todos os fatores de confusão.
Periodontitis is an inflammatory disease that affects the supporting tissues of the teeth, mainly caused by Gram-negative bacteria that adhere to the surfaces of the teeth and are organized into a complex structure, plaque. A sine qua non condition for the clinical manifestation of this pathology to occur is the presence of one or more periodontal pathogens of a specific type and in sufficient quantity that belong mainly to the red complex. Several clinical and experimental studies have highlighted the presence of a strong association between periodontal diseases and some systemic diseases, and the hypothesis that periodontal diseases may have direct systemic effects (through the spread of pathogenic bacteria) and indirect effects (through their contribution to systemic inflammation) represent the theoretical basis for understanding and studying the relationship between periodontitis and other diseases. One of the main pathologies related to the oral cavity and periodontitis is cardiovascular pathology, and the correlations between the two pathologies are mainly related to atherosclerosis. The objective of this integrative review is to understand the association between periodontitis and atherosclerosis, factors and mechanisms through which there may be a relationship. For this, a bibliographic search was carried out in the PubMed and B-On databases, following the guidelines of the PRISMA fluoxogram and PICO strategy and defining inclusion and exclusion criteria. This research resulted in 12 articles that were included in the integrative review. The results obtained by the various studies establish a link between periodontal disease and atherosclerosis and these two pathologies have risk factors in common, however, the mechanisms that relate both still need future investigations. Further longitudinal studies are needed, according to more specific classifications of periodontal disease and controlling for all confounding factors.
Periodontitis is an inflammatory disease that affects the supporting tissues of the teeth, mainly caused by Gram-negative bacteria that adhere to the surfaces of the teeth and are organized into a complex structure, plaque. A sine qua non condition for the clinical manifestation of this pathology to occur is the presence of one or more periodontal pathogens of a specific type and in sufficient quantity that belong mainly to the red complex. Several clinical and experimental studies have highlighted the presence of a strong association between periodontal diseases and some systemic diseases, and the hypothesis that periodontal diseases may have direct systemic effects (through the spread of pathogenic bacteria) and indirect effects (through their contribution to systemic inflammation) represent the theoretical basis for understanding and studying the relationship between periodontitis and other diseases. One of the main pathologies related to the oral cavity and periodontitis is cardiovascular pathology, and the correlations between the two pathologies are mainly related to atherosclerosis. The objective of this integrative review is to understand the association between periodontitis and atherosclerosis, factors and mechanisms through which there may be a relationship. For this, a bibliographic search was carried out in the PubMed and B-On databases, following the guidelines of the PRISMA fluoxogram and PICO strategy and defining inclusion and exclusion criteria. This research resulted in 12 articles that were included in the integrative review. The results obtained by the various studies establish a link between periodontal disease and atherosclerosis and these two pathologies have risk factors in common, however, the mechanisms that relate both still need future investigations. Further longitudinal studies are needed, according to more specific classifications of periodontal disease and controlling for all confounding factors.
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Keywords
Doença periodontal Periodontite Aterosclerose Relação Correlação Periodontal disease Periodontitis Atherosclerosis Relation Correlation