Publication
A utilização dos antibióticos locais como adjuvante no tratamento da periodontite crónica: revisão narrativa
| Name: | Description: | Size: | Format: | |
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| Projeto de pós-graduação_39567 | 4.91 MB | Adobe PDF |
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Abstract(s)
A periodontite crónica é uma infeção bacteriana que afeta tecidos de suporte dos dentes. É causada por uma acumulação de placa bacteriana nos dentes e gengivas, levando à inflamação desses tecidos e consequente perda de inserção. Atualmente, a raspagem e alisamento radicular (RAR) é um tratamento importante na periodontite. No entanto, devido de profundidade de bolsa aumentada e às vezes anatomia complexa do dente, a RAR sozinha não pode remover todos os patógenos presentes. Portanto, nalguns casos clínicos, a RAR pode ter um melhor efeito terapêutico se for combinado com o uso de antibióticos, o que pode reduzir o número de baterias responsáveis pela infeção e impedir a progressão da doença. A abordagem tradicional para administrar antibióticos no tratamento da periodontite crónica é administrar de forma sistémica. De acordo com os artigos científicos, a aplicação local de antibióticos (metronidazol) parece ser uma boa solução para o tratamento da periodontite porque tem muitas vantagens, como altas concentrações farmacologicamente ativas nos locais-alvo. No entanto, este método de tratamento deve ser usado com cautela, pois pode apresentar riscos de efeitos colaterais e resistência a antibióticos. A administração local de medicamentos deve funcionar como alternativa ou adjuvante ao tratamento convencional e não isoladamente.
O objetivo desta revisão narrativa com critérios sistematizados é estudar os diferentes tipos de antibióticos locais existentes (modo de administração: liberação controlada), bem como protocolos de tratamento e resultados clínicos. Isso pode incluir uma análise de estudos existentes, uma meta-análise ou até mesmo a realização de um ensaio clínico para avaliar a eficácia de um novo antibiótico local e enfatizando as diferenças de eficácia entre os antibióticos. Esta revisão enfoca a segurança e eficácia da administração local de antibióticos em comparação com a administração sistémica e discute as recomendações clínicas atuais.
Chronic periodontitis is a bacterial infection that affects the supporting tissues of the teeth. It is caused by an accumulation of bacterial plaque on the teeth and gums, leading to inflammation of these tissues and consequent loss of attachment. Currently, scaling and root planning (RAR) is an important treatment for periodontitis. However, due to increased pocket depth and sometimes complex tooth anatomy, RAR alone cannot remove all the pathogens present. Therefore, in some clinical cases, RAR can have a better therapeutic effect if it is combined with the use of antibiotics, which can reduce the number of batteries responsible for the infection and prevent the progression of the disease. The traditional approach to administering antibiotics in the treatment of chronic periodontitis is to administer them systemically. According to scientific articles, the local application of antibiotics (metronidazole) seems to be a good solution for the treatment of periodontitis because it has many advantages, such as high pharmacologically active concentrations at the target sites. However, this method of treatment should be used with caution, as it can present risks of side effects and antibiotic resistance. Local drug administration should work as an alternative or adjunct to conventional treatment and not in isolation. The aim of this narrative review with systematized criteria is to study the different types of local antibiotics that exist (mode of administration: controlled release), as well as treatment protocols and clinical results. This could include an analysis of existing studies, a meta-analysis or even conducting a clinical trial to assess the efficacy of a new local antibiotic and emphasizing the differences in efficacy between antibiotics. This review focuses on the safety and efficacy of local antibiotic administration compared to systemic administration and discusses current clinical recommendations.
Chronic periodontitis is a bacterial infection that affects the supporting tissues of the teeth. It is caused by an accumulation of bacterial plaque on the teeth and gums, leading to inflammation of these tissues and consequent loss of attachment. Currently, scaling and root planning (RAR) is an important treatment for periodontitis. However, due to increased pocket depth and sometimes complex tooth anatomy, RAR alone cannot remove all the pathogens present. Therefore, in some clinical cases, RAR can have a better therapeutic effect if it is combined with the use of antibiotics, which can reduce the number of batteries responsible for the infection and prevent the progression of the disease. The traditional approach to administering antibiotics in the treatment of chronic periodontitis is to administer them systemically. According to scientific articles, the local application of antibiotics (metronidazole) seems to be a good solution for the treatment of periodontitis because it has many advantages, such as high pharmacologically active concentrations at the target sites. However, this method of treatment should be used with caution, as it can present risks of side effects and antibiotic resistance. Local drug administration should work as an alternative or adjunct to conventional treatment and not in isolation. The aim of this narrative review with systematized criteria is to study the different types of local antibiotics that exist (mode of administration: controlled release), as well as treatment protocols and clinical results. This could include an analysis of existing studies, a meta-analysis or even conducting a clinical trial to assess the efficacy of a new local antibiotic and emphasizing the differences in efficacy between antibiotics. This review focuses on the safety and efficacy of local antibiotic administration compared to systemic administration and discusses current clinical recommendations.
Description
Keywords
Periodontics Topical antibiotics Comparison Treatment Efficiency