Loading...
Publication
Microbioma intestinal associado às doenças inflamatórias do intestino
| Name: | Description: | Size: | Format: | |
|---|---|---|---|---|
| PPG_36563 | 828.55 KB | Adobe PDF |
Authors
Advisor(s)
Abstract(s)
O Microbioma Humano é definido como a comunidade de microrganismos e dos seus
genes, que colonizam o corpo humano. A evolução e desenvolvimento do microbioma
humano é um processo dinâmico que varia ao longo da vida coexistindo em sinergia com
o hospedeiro.
É no trato gastrointestinal, mais precisamente no intestino, o local do organismo humano
que alberga maior número e diversidade de microrganismos e onde se verifica uma maior
influência e maior ação sobre os mecanismos homeostáticos humanos. O constante
dinamismo do microbioma intestinal pode ser influenciado por variados fatores, tais
como: a dieta, o estilo de vida, a idade e a exposição a fatores ambientais diversos.
As alterações inerentes ao processo dinâmico do microbioma, e consequentemente da
homeostasia do hospedeiro, podem traduzir-se no desenvolvimento de diversas patologias
e condições, nomeadamente em doenças inflamatórias do intestino. Contudo, as
consequências destas alterações podem ser diminuídas por ação isolada ou combinada de
vários fatores, por exemplo: da dieta, através do sinergismo entre os alimentos e os seus
componentes, das terapias medicamentosas, recorrendo ao uso de probióticos e pré bióticos ou de métodos de transplante bacteriano fecal. Estes tipos de intervenções
permitem modificar e reequilibrar o microbioma humano, prevenindo o desenvolvimento
e progressão de doenças e promovendo uma vida mais saudável.
Apesar de já estabelecida a marcada importância do microbioma humano e de ser alvo de
diversos estudos ao longo do tempo, há ainda um longo caminho a percorrer no que diz
respeito à correlação do microbioma e das patologias associadas às suas alterações e nos
tratamentos associados às alterações funcionais do microbioma que resultam em
alterações na sinergia com o hospedeiro.
The human microbiome is defined as an ecosystem formed by the microorganisms and their genes which colonizes the human body. The evolution and development of the human microbiome is a dynamic process that changes through all life coexisting in synergy with the host. It is in the gastrointestinal tract, more precisely in the bowel, the place of the human organism that hosts the larger number and bigger diversity of the microorganisms and where there is a bigger influence in the human homeostatic process. The gut microbiome dynamism can be influenced by a several number of factors such as: diet, lifestyle, age, and exposure to different environmental factors. The changes inherent to the dynamic process of the microbiome, and consequently to the host's homeostasis, can translate into the development of several pathologies and conditions, for instance inflammatory bowel diseases. However, the consequences of these changes can be reduced by isolated or combined action of several approaches, for example: diet, through the synergism between food and its components, pharmacologic therapies, using probiotics and prebiotics or fecal bacterial transplantation methods. These kinds of interventions allow modifying and rebalancing the human microbiome, preventing the development and progression of diseases, and promoting a healthier life. Although the marked importance of the human microbiome has been established and has been the subject of several studies over time, there is still a long way to go regarding the correlation of the microbiome and the pathologies associated with its changes and the treatments associated with the changes of the microbiome that result in changes in synergy with the host.
The human microbiome is defined as an ecosystem formed by the microorganisms and their genes which colonizes the human body. The evolution and development of the human microbiome is a dynamic process that changes through all life coexisting in synergy with the host. It is in the gastrointestinal tract, more precisely in the bowel, the place of the human organism that hosts the larger number and bigger diversity of the microorganisms and where there is a bigger influence in the human homeostatic process. The gut microbiome dynamism can be influenced by a several number of factors such as: diet, lifestyle, age, and exposure to different environmental factors. The changes inherent to the dynamic process of the microbiome, and consequently to the host's homeostasis, can translate into the development of several pathologies and conditions, for instance inflammatory bowel diseases. However, the consequences of these changes can be reduced by isolated or combined action of several approaches, for example: diet, through the synergism between food and its components, pharmacologic therapies, using probiotics and prebiotics or fecal bacterial transplantation methods. These kinds of interventions allow modifying and rebalancing the human microbiome, preventing the development and progression of diseases, and promoting a healthier life. Although the marked importance of the human microbiome has been established and has been the subject of several studies over time, there is still a long way to go regarding the correlation of the microbiome and the pathologies associated with its changes and the treatments associated with the changes of the microbiome that result in changes in synergy with the host.
Description
Keywords
Microbioma intestinal humano Doença inflamatória do intestino Biofilmes Probiótico Prebióticos Doença de Crohn Colite ulcerosa Human intestinal microbioma Inflammatory bowel disease Biofilms Probiotics Prebiotics Crohn's disease Ulcerative colitis