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Estudo da eficácia dos dentífricos contendo clorexidina na microbiota oral: revisão sistemática
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| Projeto de pós-graduação_38429 | 494.71 KB | Adobe PDF |
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A clorexidina (CHX) é uma das substâncias antissépticas mais eficazes e, portanto, mais populares utilizadas na medicina dentária. É um dos compostos de pastas de dentes, colutórios orais, géis pós-operatórios e medicamentos sendo o colutório de CHX um dos agentes antimicrobianos mais utilizados pelos profissionais de saúde oral, bem como pelo público com e sem doenças orais, para reduzir a carga bacteriana na cavidade oral com o pretexto de prevenir e controlar as doenças orais. Esta revisão sistemática tem como objetivo investigar a eficácia da utilização de CHX no microbioma oral. A revisão sistemática abrange doze estudos que investigam o impacto de colutórios com clorexidina na composição e na diversidade da microbiota oral, além de avaliar os efeitos clínicos associados à sua utilização e que atendiam aos critérios de elegibilidade propostos. Os estudos incluídos nesta revisão sistemática mostram que a CHX, quando utilizada em colutórios, pode reduzir a quantidade de microrganismos patogénicos, como Streptococcus mutans e Porphyromonas gingivalis, melhorando os indicadores de saúde periodontal e reduzindo a inflamação. No entanto, também foram observados efeitos adversos, como a alteração do sabor e o aumento da formação de manchas dentárias. A análise dos dados disponíveis sugere que a CHX é uma ferramenta eficaz no controlo do microbioma oral, mas a sua utilização deve ser monitorizada para evitar possíveis efeitos adversos. Destaca-se também a necessidade de mais estudos longitudinais para confirmar os efeitos a longo prazo da CHX sobre o microbioma oral.
Chlorhexidine (CHX) is one of the most effective and therefore most popular antiseptic substances used in dentistry. It is one of the components of toothpastes, mouthwashes, postoperative gels and medications, with CHX mouthwash being one of the most widely used antimicrobial agents by oral health professionals, as well as by the public with and without oral diseases, to reduce the bacterial load in the oral cavity under the pretext of preventing and controlling oral diseases. This systematic review aims to investigate the efficacy of CHX use on the oral microbiome. The systematic review covers twelve studies that investigate the impact of chlorhexidine mouthwashes on the composition and diversity of the oral microbiota, in addition to evaluating the clinical effects associated with its use and that met the proposed eligibility criteria. The studies included in this systematic review show that CHX, when used in mouthwashes, can reduce the number of pathogenic microorganisms, such as Streptococcus mutans and Porphyromonas gingivalis, improving periodontal health indicators and reducing inflammation. However, adverse effects, such as altered taste and increased formation of dental stains, have also been observed. Analysis of the available data suggests that CHX is an effective tool in controlling the oral microbiome, but its use should be monitored to avoid possible adverse effects. It is also worth highlighting the need for further longitudinal studies to confirm the long-term effects of CHX on the oral microbiome.
Chlorhexidine (CHX) is one of the most effective and therefore most popular antiseptic substances used in dentistry. It is one of the components of toothpastes, mouthwashes, postoperative gels and medications, with CHX mouthwash being one of the most widely used antimicrobial agents by oral health professionals, as well as by the public with and without oral diseases, to reduce the bacterial load in the oral cavity under the pretext of preventing and controlling oral diseases. This systematic review aims to investigate the efficacy of CHX use on the oral microbiome. The systematic review covers twelve studies that investigate the impact of chlorhexidine mouthwashes on the composition and diversity of the oral microbiota, in addition to evaluating the clinical effects associated with its use and that met the proposed eligibility criteria. The studies included in this systematic review show that CHX, when used in mouthwashes, can reduce the number of pathogenic microorganisms, such as Streptococcus mutans and Porphyromonas gingivalis, improving periodontal health indicators and reducing inflammation. However, adverse effects, such as altered taste and increased formation of dental stains, have also been observed. Analysis of the available data suggests that CHX is an effective tool in controlling the oral microbiome, but its use should be monitored to avoid possible adverse effects. It is also worth highlighting the need for further longitudinal studies to confirm the long-term effects of CHX on the oral microbiome.
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Palavras-chave
Clorexidina Colutório Microbioma oral Doença periodontal Chlorhexidine Mouthwash Oral microbiome Periodontal disease