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Florotaninos na prevenção e tratamento de doenças oncológicas
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| 34992 | 554.99 KB | Adobe PDF |
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Abstract(s)
O aumento da prevalência das doenças oncológicas e as limitações (efeitos secundários e ocorrência de resistências) associadas às terapias tradicionais, como a quimioterapia e a radioterapia, realçam a necessidade de encontrar substâncias mais eficazes no tratamento destas patologias.
O oceano é um ambiente rico em diversidade, tanto de organismos quanto de recursos naturais. Dentro dos recursos marinhos, as algas, utilizadas há vários séculos na alimentação e como remédios tradicionais, são uma fonte ainda pouco explorada a nível global, por isso nos últimos anos têm sido um dos focos da pesquisa científica tendo alguns estudos já demonstrado o seu potencial em diferentes áreas científicas.
Neste contexto, nos últimos anos têm surgido vários trabalhos de investigação com o objetivo de descobrir, de entre os inúmeros metabolitos das algas, moléculas bioativas com propriedades antineoplásicas. Os florotaninos constituem um grupo importante de compostos fenólicos sintetizados pelas algas castanhas, com comprovada importância para a saúde humana, nomeadamente pelas suas propriedades antioxidante, anti- -inflamatória, antibacteriana, entre outras. Mais recentemente estes compostos emergiram como quimiopreventivos e quimio-protetores regulando as diferentes vias de morte celular.
Com este trabalho de revisão bibliográfica pretende-se fornecer uma visão global e atualizada dos diferentes florotaninos com potencial antineoplásico e abordar os diferentes estudos in vitro e in vivo que têm vindo a comprovar as vantagens do uso destes compostos na prevenção e tratamento de doenças oncológicas.
The increase in the prevalence of cancer and the limitations (side effects and the occurrence of resistance) associated with traditional therapies, such as chemotherapy and radiotherapy, highlight the need to find more effective substances for the treatment of these diseases. The ocean is an environment rich in diversity, both in terms of organisms and natural resources. Within marine resources, seaweed, used for centuries in food and as traditional remedies, is a source that is still underexplored globally. For this reason, in recent years, it has been one of the focuses of scientific research, with some studies having already demonstrated its potential in different scientific areas. In this context, in recent years, several research works have emerged with the aim of discovering, from among the numerous metabolites of seaweed, bioactive molecules with antineoplastic properties. Phlorotannins are an important group of phenolic compounds synthesized by brown algae, with proven importance for human health, notably for their antioxidant, anti-inflammatory, and antibacterial properties, among others. More recently, these compounds have emerged as chemo preventive and chemoprotective agents, regulating the different cell death pathways. With this bibliographic review, it is intended to provide a global and updated overview of the different phlorotannins with antineoplastic potential and to address the different in vitro and in vivo studies that have been proving the advantages of using these compounds in the prevention and treatment of cancer.
The increase in the prevalence of cancer and the limitations (side effects and the occurrence of resistance) associated with traditional therapies, such as chemotherapy and radiotherapy, highlight the need to find more effective substances for the treatment of these diseases. The ocean is an environment rich in diversity, both in terms of organisms and natural resources. Within marine resources, seaweed, used for centuries in food and as traditional remedies, is a source that is still underexplored globally. For this reason, in recent years, it has been one of the focuses of scientific research, with some studies having already demonstrated its potential in different scientific areas. In this context, in recent years, several research works have emerged with the aim of discovering, from among the numerous metabolites of seaweed, bioactive molecules with antineoplastic properties. Phlorotannins are an important group of phenolic compounds synthesized by brown algae, with proven importance for human health, notably for their antioxidant, anti-inflammatory, and antibacterial properties, among others. More recently, these compounds have emerged as chemo preventive and chemoprotective agents, regulating the different cell death pathways. With this bibliographic review, it is intended to provide a global and updated overview of the different phlorotannins with antineoplastic potential and to address the different in vitro and in vivo studies that have been proving the advantages of using these compounds in the prevention and treatment of cancer.
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Keywords
Macroalgas castanhas Florotaninos Ecois Ação antineoplásica Brown macroalgae Phlorotannins Eckols Antineoplastic action