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Impacto do gene p53 no prognóstico e tratamento dos carcinomas espinocelulares orais: revisão
| Name: | Description: | Size: | Format: | |
|---|---|---|---|---|
| Projeto de pós-graduação_39499 | 1.38 MB | Adobe PDF |
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Abstract(s)
Introdução: O carcinoma espinocelular oral é um tumor maligno prevalente na cavidade oral, representando uma das principais causas de mortalidade entre os cancros de cabeça e pescoço. Sua etiologia está associada a fatores de risco como tabagismo, álcool e HPV.
O gene TP53 codifica a proteína p53, um supressor tumoral essencial na integridade genómica. A p53 atua como fator de transcrição, regulando a reparação do ADN, o ciclo celular e a apoptose. Em condições normais, previne a proliferação de células com ADN danificado, evitando tumores malignos. Mutações no TP53 são comuns em diversos cancros, incluindo o carcinoma espinocelular oral. Essas mutações podem levar à perda da função supressora ou à aquisição de funções oncogénicas. Consequentemente, há proliferação celular descontrolada e aumento da resistência tumoral a terapias convencionais. Compreender o papel das mutações do TP53 no carcinoma espinocelular oral é essencial para aprimorar estratégias diagnósticas e terapêuticas. Estudos indicam que essas mutações podem servir como biomarcadores para triagem de lesões orais malignas. A investigação detalhada das alterações no TP53 e seu impacto no comportamento do carcinoma espinocelular oral é crucial para desenvolver terapias mais eficazes, melhorando prognóstico e qualidade de vida dos pacientes.
Objetivo: O objetivo deste trabalho foi determinar o impacto do gene P53 no pronóstico e no tratamento dos carcinomas espinocelulares orais.
Metodologia: Foram utilizadas as bases de dados digitais: PubMed e ScienceDirect. Foram aplicados os marcadores “AND” e “OR”. Foram estipulados critérios de inclusão, nomeadamente, artigos publicados nos últimos dez anos (2014-2024), maioritariamente em idioma inglês, mas, também em francês e português, contendo informação relevante sobre os carcinomas espinocelulares orais, a proteína p53 e suas mutações e as estratégias terapêuticas. A pesquisa englobou artigos de revisões narrativas, revisões sistemáticas, meta-análises, sites governamentais e uma tese de doutoramento. Os critérios de exclusão são os artigos com resumos inacessíveis.
Introduction: Oral squamous cell carcinoma is a malignant tumor prevalent in the oral cavity, representing one of the main causes of mortality among head and neck cancers. Its etiology is associated with risk factors such as smoking, alcohol and HPV. The TP53 gene encodes the p53 protein, an essential tumor suppressor for genomic integrity. p53 acts as a transcription factor, regulating DNA repair, the cell cycle and apoptosis. Under normal conditions, it prevents the proliferation of cells with damaged DNA, preventing malignant tumors. Mutations in TP53 are common in several cancers, including oral squamous cell carcinoma. These mutations can lead to the loss of suppressive function or the acquisition of oncogenic functions. Consequently, there is uncontrolled cell proliferation and increased tumor resistance to conventional therapies. Understanding the role of TP53 mutations in oral squamous cell carcinoma is essential for improving diagnostic and therapeutic strategies. Studies indicate that these mutations can serve as biomarkers for screening malignant oral lesions. Detailed investigation of TP53 alterations and their impact on the behavior of oral squamous cell carcinoma is crucial to developing more effective therapies, improving prognosis and quality of life for patients. Objective: The aim of this study was to determine the impact of the P53 gene on the prognosis and treatment of oral squamous cell carcinomas. Methodology: PubMed and ScienceDirect digital databases were used. The ‘AND’ and ‘OR’ markers were applied. Inclusion criteria were stipulated, namely articles published in the last ten years (2014-2024), mostly in English, but also in French and Portuguese, containing relevant information on oral squamous cell carcinomas, the p53 protein and its mutations and therapeutic strategies. The search included articles from narrative reviews, systematic reviews, meta-analyses, government websites and a doctoral thesis. The exclusion criteria were articles with inaccessible abstracts.
Introduction: Oral squamous cell carcinoma is a malignant tumor prevalent in the oral cavity, representing one of the main causes of mortality among head and neck cancers. Its etiology is associated with risk factors such as smoking, alcohol and HPV. The TP53 gene encodes the p53 protein, an essential tumor suppressor for genomic integrity. p53 acts as a transcription factor, regulating DNA repair, the cell cycle and apoptosis. Under normal conditions, it prevents the proliferation of cells with damaged DNA, preventing malignant tumors. Mutations in TP53 are common in several cancers, including oral squamous cell carcinoma. These mutations can lead to the loss of suppressive function or the acquisition of oncogenic functions. Consequently, there is uncontrolled cell proliferation and increased tumor resistance to conventional therapies. Understanding the role of TP53 mutations in oral squamous cell carcinoma is essential for improving diagnostic and therapeutic strategies. Studies indicate that these mutations can serve as biomarkers for screening malignant oral lesions. Detailed investigation of TP53 alterations and their impact on the behavior of oral squamous cell carcinoma is crucial to developing more effective therapies, improving prognosis and quality of life for patients. Objective: The aim of this study was to determine the impact of the P53 gene on the prognosis and treatment of oral squamous cell carcinomas. Methodology: PubMed and ScienceDirect digital databases were used. The ‘AND’ and ‘OR’ markers were applied. Inclusion criteria were stipulated, namely articles published in the last ten years (2014-2024), mostly in English, but also in French and Portuguese, containing relevant information on oral squamous cell carcinomas, the p53 protein and its mutations and therapeutic strategies. The search included articles from narrative reviews, systematic reviews, meta-analyses, government websites and a doctoral thesis. The exclusion criteria were articles with inaccessible abstracts.
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Keywords
Oral squamous cell carcinoma p53 Head and neck squamous cell carcinoma Prognostic Treatment