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A peri-implantite é uma complicação comum em pacientes com implantes dentários, caracterizada pela inflamação dos tecidos ao redor do implante e perda óssea progressiva. O tratamento eficaz da peri-implantite envolve a remoção do biofilme bacteriano, a desinfecção da superfície do implante e a regeneração dos tecidos danificados. A combinação de hipoclorito de sódio/aminoácidos e ácido hialurónico reticulado (xHyA) tem se mostrado uma abordagem terapêutica promissora, tanto em modelos experimentais quanto em estudos clínicos de doenças periodontais. Desta forma, o objetivo desta revisão narrativa é avaliar a eficácia dessa combinação para reduzir a inflamação e limitar a progressão da peri-implantite, com base na literatura científica existente. Para tal foi realizada uma pesquisa bibliográfica nas bases de dados PubMed, Cochrane Library e ScienceDirect, aplicando critérios de elegibilidade pré-definidos. Os estudos incluídos demonstram que o hipoclorito de sódio é eficaz na eliminação de biofilmes bacterianos patogénicos, enquanto o xHyA promove a regeneração óssea e tecidual, reduzindo a inflamação e acelerando a cicatrização. Apesar da maioria dos estudos serem focados na periodontite, os mecanismos compartilhados entre periodontite e peri-implantite tornam essa combinação terapêutica uma opção viável para o tratamento de peri-implantite, especialmente em casos iniciais e moderados da doença. No entanto, mais estudos clínicos específicos sobre peri-implantite são necessários para validar a eficácia e segurança dessa abordagem.
Peri-implantitis is a common complication in patients with dental implants, characterized by inflammation of the tissues surrounding the implant and progressive bone loss. Effective treatment of peri-implantitis involves the removal of bacterial biofilm, disinfection of the implant surface and regeneration of damaged tissues. The combination of sodium hypochlorite/amino acids and cross-linked hyaluronic acid (xHyA) has shown to be a promising therapeutic approach, both in experimental models and in clinical studies of periodontal diseases. Therefore, the objective of this narrative review is to evaluate the efficacy of this combination in reducing inflammation and limiting the progression of peri-implantitis, based on the existing scientific literature. For this purpose, a bibliographic search was performed in the PubMed, Cochrane Library and ScienceDirect databases, applying pre-defined eligibility criteria. The included studies demonstrate that sodium hypochlorite is effective in eliminating pathogenic bacterial biofilms, while xHyA promotes bone and tissue regeneration, reducing inflammation and accelerating healing. Although most studies have focused on periodontitis, the shared mechanisms between periodontitis and peri-implantitis make this therapeutic combination a viable option for the treatment of peri-implantitis, especially in early and moderate cases of the disease. However, further clinical studies specific to peri-implantitis are needed to validate the efficacy and safety of this approach.
Peri-implantitis is a common complication in patients with dental implants, characterized by inflammation of the tissues surrounding the implant and progressive bone loss. Effective treatment of peri-implantitis involves the removal of bacterial biofilm, disinfection of the implant surface and regeneration of damaged tissues. The combination of sodium hypochlorite/amino acids and cross-linked hyaluronic acid (xHyA) has shown to be a promising therapeutic approach, both in experimental models and in clinical studies of periodontal diseases. Therefore, the objective of this narrative review is to evaluate the efficacy of this combination in reducing inflammation and limiting the progression of peri-implantitis, based on the existing scientific literature. For this purpose, a bibliographic search was performed in the PubMed, Cochrane Library and ScienceDirect databases, applying pre-defined eligibility criteria. The included studies demonstrate that sodium hypochlorite is effective in eliminating pathogenic bacterial biofilms, while xHyA promotes bone and tissue regeneration, reducing inflammation and accelerating healing. Although most studies have focused on periodontitis, the shared mechanisms between periodontitis and peri-implantitis make this therapeutic combination a viable option for the treatment of peri-implantitis, especially in early and moderate cases of the disease. However, further clinical studies specific to peri-implantitis are needed to validate the efficacy and safety of this approach.
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Peri-implantite Hipoclorito de sódio/aminoácido Hipoclorito de sódio Ácido hialurónico reticulado Periimplantitis Sodium hypochlorite/amino acid Sodium hypochlorite Cross-linked hyaluronic acid