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Non-lamellar lipid nanosystems for topical application
| Name: | Description: | Size: | Format: | |
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| Projeto de pós-graduação_2022104991 | 1.6 MB | Adobe PDF |
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Abstract(s)
A presente dissertação analisa o potencial dos nanossistemas lipídicos não lamelares para a aplicação tópica de fármacos, com enfoque nas suas vantagens e aplicações na administração cutânea, ocular e vaginal. O estudo está estruturado em três seções principais: uma análise dos benefícios e desafios da administração tópica de fármacos, uma análise dos nanossistemas lipídicos não lamelares, que incluem os cubossomas, hexossomas e esponjossomas, e uma discussão dos resultados no contexto da literatura existente.
Os nanosistemas lipídicos não lamelares formam nanoestruturas únicas capazes de encapsular vários agentes terapêuticos, melhorando a solubilidade, estabilidade e biodisponibilidade dos fármacos, e oferecem a possibilidade de controlar o perfil de libertação. Estes nanossistemas têm demonstrado potencial em superar as limitações das formas farmacêuticas convencionais, tornando-os adequados para diversas aplicações farmacêuticas, cosméticas e biomédicas.
O estudo para elaborar esta dissertação baseou-se numa análise bibliográfica e discussão das principais barreiras fisiológicas à permeação de fármacos quando administrados por via tópica, nomeadamente na aplicação cutânea, ocular e vaginal. São explorados os métodos de preparação e as aplicações dos cubossomas, hexossomas e esponjossomas, com uma avaliação detalhada da sua eficácia na administração tópica.
Os principais resultados deste estudo indicam que os nanossistemas lipídicos não lamelares aumentam a penetração e a libertação de fármacos nas aplicações cutâneas, revelando-se eficazes para determinadas condições da pele, como infeções, inflamação e queimaduras. Na administração ocular, estes nanossistemas melhoram a biodisponibilidade e a penetração dos fármacos, beneficiando tratamentos para glaucoma, infeções bacterianas e inflamação. Para a administração vaginal, os cubossomas demonstram-se promissores no controlo da libertação de fármacos e na melhoria da eficácia terapêutica, particularmente para infeções e tratamentos localizados.
Apesar dos resultados promissores, permanecem desafios para a produção em grande escala, aprovação regulatória e necessidade de ensaios clínicos. Garantir a reprodutibilidade e a escalabilidade é crucial para a aplicação bem-sucedida destes nanosistemas na prática clínica. Pesquisas futuras devem focar na otimização das formulações, identificação de outros fármacos que possam beneficiar deste tipo de veiculação e realização de ensaios clínicos de maior escala para confirmar a sua eficácia e segurança.
Em conclusão, os nanossistemas lipídicos não lamelares representam uma estratégia inovadora para a administração tópica de fármacos, oferecendo vantagens significativas sobre as abordagens tradicionais. A sua capacidade de melhorar os resultados da administração de medicamentos em várias vias sublinha o seu potencial para revolucionar as aplicações terapêuticas, necessitando de mais pesquisa e colaboração interdisciplinar para realizar todo o seu potencial clínico.
The present dissertation analyses the potential of non-lamellar lipid nanosystems for topical application of drugs, focusing on their advantages and applications in skin, ocular, and vaginal administration. The study is structured into three main sections: an analysis of topical drug delivery benefits and challenges, an analysis of non-lamellar lipid nanosystems, which include cubosomes, hexosomes, and spongosomes, and a discussion of the findings in the context of the existing literature. Non-lamellar lipid nanosystems form unique nanostructures capable of encapsulating various therapeutic agents, improving drug solubility, stability, and bioavailability, and offer the possibility of controlling the release profile. These nanosystems have shown potential in overcoming the limitations of conventional pharmaceutical dosage forms, making them suitable for diverse pharmaceutical, cosmetic, and biomedical applications. The study of this dissertation was based on bibliographic analysis and discussion of the main physiological barriers to the permeation of drugs when administered topically, namely in cutaneous, ocular, and vaginal routes. The preparation methods and applications of cubosomes, hexosomes, and spongosomes are explored, with a detailed evaluation of their efficacy in topical administration. The main results of this study indicate that non-lamellar lipid nanosystems enhance drug penetration and release in skin applications, proving effective for certain skin conditions like infections, inflammation, and burns. In ocular drug delivery, these nanosystems improve drug bioavailability and penetration, benefiting treatments for glaucoma, bacterial infections, and inflammation. For vaginal delivery, cubosomes show promise in sustaining drug release and enhancing therapeutic efficacy, particularly for infections and localized treatments. Despite the promising results, challenges remain for large-scale production, regulatory approval, and the need for extensive clinical trials. Ensuring reproducibility and scalability is critical for the successful translation of these nanosystems into clinical practice. Future research should focus on optimizing formulations, identifying other drugs that could benefit from this nanocarriers and conducting larger-scale clinical trials to confirm their efficacy and safety. In conclusion, non-lamellar lipid nanosystems represent a cutting-edge strategy for topical drug administration, offering significant advantages over traditional approaches. Their ability to improve drug delivery outcomes across various routes underscores their potential to revolutionize therapeutic applications, necessitating further research and interdisciplinary collaboration to realize their full clinical potential.
The present dissertation analyses the potential of non-lamellar lipid nanosystems for topical application of drugs, focusing on their advantages and applications in skin, ocular, and vaginal administration. The study is structured into three main sections: an analysis of topical drug delivery benefits and challenges, an analysis of non-lamellar lipid nanosystems, which include cubosomes, hexosomes, and spongosomes, and a discussion of the findings in the context of the existing literature. Non-lamellar lipid nanosystems form unique nanostructures capable of encapsulating various therapeutic agents, improving drug solubility, stability, and bioavailability, and offer the possibility of controlling the release profile. These nanosystems have shown potential in overcoming the limitations of conventional pharmaceutical dosage forms, making them suitable for diverse pharmaceutical, cosmetic, and biomedical applications. The study of this dissertation was based on bibliographic analysis and discussion of the main physiological barriers to the permeation of drugs when administered topically, namely in cutaneous, ocular, and vaginal routes. The preparation methods and applications of cubosomes, hexosomes, and spongosomes are explored, with a detailed evaluation of their efficacy in topical administration. The main results of this study indicate that non-lamellar lipid nanosystems enhance drug penetration and release in skin applications, proving effective for certain skin conditions like infections, inflammation, and burns. In ocular drug delivery, these nanosystems improve drug bioavailability and penetration, benefiting treatments for glaucoma, bacterial infections, and inflammation. For vaginal delivery, cubosomes show promise in sustaining drug release and enhancing therapeutic efficacy, particularly for infections and localized treatments. Despite the promising results, challenges remain for large-scale production, regulatory approval, and the need for extensive clinical trials. Ensuring reproducibility and scalability is critical for the successful translation of these nanosystems into clinical practice. Future research should focus on optimizing formulations, identifying other drugs that could benefit from this nanocarriers and conducting larger-scale clinical trials to confirm their efficacy and safety. In conclusion, non-lamellar lipid nanosystems represent a cutting-edge strategy for topical drug administration, offering significant advantages over traditional approaches. Their ability to improve drug delivery outcomes across various routes underscores their potential to revolutionize therapeutic applications, necessitating further research and interdisciplinary collaboration to realize their full clinical potential.
Description
Keywords
Cubossomas Hexossomas Esponjossomas Administração tópica Administração cutânea Administração ocular Administração vaginal Cubosomes Hexosomes Spongosomes Topical administration Skin administration Ocular administration Vaginal administration