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A psoríase
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Abstract(s)
A psoríase é uma doença dermatológica inflamatória e crónica, de origem auto-imune e de ocorrência universal, que acomete igualmente homens e mulheres, em Portugal e no mundo. Carateriza-se pela presença de placas eritemato-descamativas e alterações articulares com graus variados de intensidade. A psoríase altera de modo importante a qualidade de vida de seus portadores.
Os mecanismos responsáveis por esta doença ainda não estão totalmente esclarecidos, sendo provavelmente multifatoriais, envolvendo fatores genéticos, imunológicos e ambientais.
Têm-se verificado um grande número de doenças sistémicas associadas à psoríase, tais como artrite psoriática, linfomas cutâneos de células T e outras doenças envolvendo os sistemas articular, gastrointestinal, cardiocirculatório e endócrino.
Apesar do número de tratamentos existentes, muitos dos doentes com psoríase exibem formas graves da doença que não são controláveis pelos tratamentos tópicos, além de que as terapêuticas sistémicas convencionais, apesar de eficazes, apresentam efeitos secundários que limitam o seu uso continuado.
Nos últimos anos, a necessidade de terapêuticas mais eficazes e seguras, associada aos avanços significativos no conhecimento da imunopatogénese da psoríase, estimularam o desenvolvimento de novas terapias, como a fototerapia e novos fármacos, como os agentes biológicos, especificamente direcionados aos mecanismos envolvidos na patogénese da doença. Os novos tratamentos da psoríase apresentam resultados bastante satisfatórios sendo, contudo, um encargo grande para o Sistema Nacional de Saúde.
Psoriasis is a chronic inflammatory skin disease of autoimmune and universal occurrence that affects both men and women, in Portugal and in the world. It is characterized by the presence of erythematous-desquamative plaques and articular alterations with varying degrees of intensity. Psoriasis changes in an important way the quality of life of its patients. The mechanisms responsible for this disease are not yet fully understood, and are probably multifactorial, involving genetic, immunological and environmental factors. There have been a large number of systemic diseases associated with psoriasis, such as psoriatic arthritis, cutaneous T-cell lymphomas and others involving the articular, gastrointestinal, cardiocirculatory and endocrine systems. Despite the number of treatments available, many psoriasis patients have severe forms of the disease that are not controllable by topical treatments. In addition, conventional systemic therapies, although effective, have side effects that limit their continued use. In recent years, the need for more effective and safe therapies associated with significant advances in the knowledge of the immunopathogenesis of psoriasis has stimulated the development of new therapies, such as phototherapy and new drugs, such as biological agents, specifically directed to the mechanisms involved in the pathogenesis of psoriasis disease. The new treatments of psoriasis present quite satisfactory results being, however, a great burden for the National Health System.
Psoriasis is a chronic inflammatory skin disease of autoimmune and universal occurrence that affects both men and women, in Portugal and in the world. It is characterized by the presence of erythematous-desquamative plaques and articular alterations with varying degrees of intensity. Psoriasis changes in an important way the quality of life of its patients. The mechanisms responsible for this disease are not yet fully understood, and are probably multifactorial, involving genetic, immunological and environmental factors. There have been a large number of systemic diseases associated with psoriasis, such as psoriatic arthritis, cutaneous T-cell lymphomas and others involving the articular, gastrointestinal, cardiocirculatory and endocrine systems. Despite the number of treatments available, many psoriasis patients have severe forms of the disease that are not controllable by topical treatments. In addition, conventional systemic therapies, although effective, have side effects that limit their continued use. In recent years, the need for more effective and safe therapies associated with significant advances in the knowledge of the immunopathogenesis of psoriasis has stimulated the development of new therapies, such as phototherapy and new drugs, such as biological agents, specifically directed to the mechanisms involved in the pathogenesis of psoriasis disease. The new treatments of psoriasis present quite satisfactory results being, however, a great burden for the National Health System.
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Keywords
Psoríase Linfócitos T Hiperproliferação de queratinócitos Dermatose Psoriasis T lymphocytes Hyperproliferation of keratinocytes Dermatosis