Publication
Genes involved in the development of autism
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Advisor(s)
Abstract(s)
Background: Autism is still considered a very complex
disease, since it has diverse etiology, with multiple factors
apparently associated with its appearance. However, none
of them reveals to be totally responsible for its development.
Nowadays, this disorder is considered to have a strong
genetic component with the interaction of several genes.
Furthermore, other diseases with well-known etiology might
also be related with autism.
Methods: The aim of this review is to discuss, through
bibliographic search, genetic factors involved in autism
development.
Results: Some of the candidate genes of idiopathic autism
(90-95% of all cases) related to brain metabolism are
AVPR1a, DISC1, DYX1C1, ITGB3, SLC6A4, RELN, RPL10
and SHANK3.
Conclusion: All these genes are responsible for symptoms
that can explain the origin of this condition. Autism is a
multifactorial disorder in which genetic and environmental
factors interact, triggering its development.
Description
Keywords
Autism spectrum disturbances Genes determining autism Idiopathic autism