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Publication
Dieta cetogénica e epilepsia refratária em crianças e adolescentes
| Name: | Description: | Size: | Format: | |
|---|---|---|---|---|
| TC_29355 | 408.14 KB | Adobe PDF |
Authors
Advisor(s)
Abstract(s)
Objetivo: Realizar uma revisão da literatura sobre a eficácia da dieta cetogénica em
crianças e adolescentes com epilepsia refratária.
Metodologia: Foi realizada uma revisão da literatura recorrendo à base de dados
Pubmed®. Apenas foram selecionadas publicações referentes aos últimos 5 anos no
idioma inglês, espanhol ou português e que incluíam estudos apenas realizados em
humanos, nomeadamente crianças desde o nascimento até aos 18 anos. Foram utilizadas
as seguintes palavras-chave: “epilepsy AND diet”, “epilepsy AND dietary therapy”,
“epilepsy AND ketogenic diet”, “epilepsy AND nutrition" e por último “epilepsy AND
nutrition care”.
Resultados: A Dieta Cetogénica é uma terapia não farmacológica usada no tratamento
da epilepsia, no entanto esta não é considerada a primeira abordagem terapêutica.
Existem diferentes variantes da Dieta Cetogénica, que combinam os três
macronutrientes de diferentes formas. As dietas menos restritivas em hidratos de
carbono e com menor percentagem de gordura são melhores toleradas, mas todas são
eficazes.
Tem sido descrito que a Dieta Cetogénica pode ter uma redução na frequência de crises
> 50%, >90% ou mesmo 100%, considerando assim que o doente está livre de crises. A
administração da Dieta Cetogénica quando corretamente aplicada, pode ainda levar a
redução ou até mesmo à descontinuação dos fármacos antiepiléticos.
Conclusão: A DC é um tratamento a ter em conta como terapia adjuvante para a
epilepsia. Este tratamento é eficaz e seguro, no entanto possui alguns efeitos
secundários. Quanto à tolerabilidade da dieta, existem variantes da DC que são mais
bem aceites do que outras.
Objective: Make a review of the literature about efficacy of ketogenic diet in children and adolescents with refractory epilepsy. Methodology: Was performed an literature review using the Pubmed database, only only publications referring to the last 5 years in the English, Spanish or Portuguese language were included and included studies only performed in humans, namely children from birth to 18 years of age. The following keywords were used: "epilepsy AND diet", "epilepsy AND dietary therapy", "epilepsy AND ketogenic diet", "epilepsy AND nutrition" and lastly "epilepsy AND nutrition care". Results: The Ketogenic Diet is a non-pharmacological therapy used in the treatment for epilepsy, however it is not considered a first therapeutic approach. There are different versions of the Ketogenic Diet, which combine the three macronutrients of different ways. The less restrictive carbohydrates and lower fat percentage diets are better tolerated, but all are efficient. It has been described as a Ketogenic Diet may have a reduction in the frequency of seizures > 50%, > 90% or even 100%, considering the patient seizure freedom. Administration of Ketogenic Diet when properly applied may further lead to a reduction or even discontinuation of antiepileptic drugs. Conclusions: Ketogenic Diet is a treatment to be considered as adjunctive therapy for epilepsy. This treatment is effective and safe, however, some side effects. As for the tolerability of the diet, there are Ketogenic Diet variants that are better accepted than others.
Objective: Make a review of the literature about efficacy of ketogenic diet in children and adolescents with refractory epilepsy. Methodology: Was performed an literature review using the Pubmed database, only only publications referring to the last 5 years in the English, Spanish or Portuguese language were included and included studies only performed in humans, namely children from birth to 18 years of age. The following keywords were used: "epilepsy AND diet", "epilepsy AND dietary therapy", "epilepsy AND ketogenic diet", "epilepsy AND nutrition" and lastly "epilepsy AND nutrition care". Results: The Ketogenic Diet is a non-pharmacological therapy used in the treatment for epilepsy, however it is not considered a first therapeutic approach. There are different versions of the Ketogenic Diet, which combine the three macronutrients of different ways. The less restrictive carbohydrates and lower fat percentage diets are better tolerated, but all are efficient. It has been described as a Ketogenic Diet may have a reduction in the frequency of seizures > 50%, > 90% or even 100%, considering the patient seizure freedom. Administration of Ketogenic Diet when properly applied may further lead to a reduction or even discontinuation of antiepileptic drugs. Conclusions: Ketogenic Diet is a treatment to be considered as adjunctive therapy for epilepsy. This treatment is effective and safe, however, some side effects. As for the tolerability of the diet, there are Ketogenic Diet variants that are better accepted than others.
Description
Trabalho Complementar apresentado à Universidade Fernando Pessoa como parte dos requisitos para obtenção do grau de licenciada em Ciências da Nutrição
Keywords
Epilepsia Crianças Eficácia Dieta cetogénica Terapêutica nutricional Epilepsy Children Efficacy Ketogenic diet Nutritional therapy