Publication
Chemiosmotic misunderstandings
| dc.contributor.author | Silva, Pedro J. | |
| dc.date.accessioned | 2020-07-24T16:16:44Z | |
| dc.date.available | 2020-07-24T16:16:44Z | |
| dc.date.issued | 2020 | |
| dc.description.abstract | Recent publications have questioned the appropriateness of the chemiosmotic theory, a key tenet of modern bioenergetics originally described by Mitchell and since widely improved upon and applied. In one of them, application of Gauss’ law to a model charge distribution in mitochondria was argued to refute the possibility of ATP generation through H+ movement in the absence of a counterion, whereas a different author advocated, for other reasons, the impossibility of chemiosmosis and proposed that a novel energy-generation scheme (referred to as “murburn”) relying on superoxide-catalyzed (or superoxide-promoted) ADP phosphorylation would operate instead. In this letter, those proposals are critically examined and found to be inconsistent with established experimental data and new theoretical calculations. | pt_PT |
| dc.description.version | info:eu-repo/semantics/acceptedVersion | pt_PT |
| dc.identifier.doi | 10.1016/j.bpc.2020.106424 | pt_PT |
| dc.identifier.uri | http://hdl.handle.net/10284/8815 | |
| dc.language.iso | eng | pt_PT |
| dc.peerreviewed | yes | pt_PT |
| dc.publisher | Elsevier | pt_PT |
| dc.relation.publisherversion | https://dx.doi.org/10.1016/j.bpc.2020.106424 | pt_PT |
| dc.subject | Bioenergetics | pt_PT |
| dc.subject | Chemiosmosis | pt_PT |
| dc.subject | Gauss’s law | pt_PT |
| dc.subject | Proton-motive force | pt_PT |
| dc.title | Chemiosmotic misunderstandings | pt_PT |
| dc.type | journal article | |
| dspace.entity.type | Publication | |
| oaire.citation.endPage | in press | pt_PT |
| oaire.citation.issue | in press | pt_PT |
| oaire.citation.startPage | in press | pt_PT |
| oaire.citation.title | Biophysical Chemistry | pt_PT |
| oaire.citation.volume | in press | pt_PT |
| person.familyName | Silva | |
| person.givenName | Pedro | |
| person.identifier.orcid | 0000-0001-9316-9275 | |
| person.identifier.scopus-author-id | 55310885700 | |
| rcaap.rights | openAccess | pt_PT |
| rcaap.type | article | pt_PT |
| relation.isAuthorOfPublication | f4a9230e-0a0e-45b6-b894-e71ded186ef2 | |
| relation.isAuthorOfPublication.latestForDiscovery | f4a9230e-0a0e-45b6-b894-e71ded186ef2 |
Files
Original bundle
1 - 1 of 1
Loading...
- Name:
- chemiosmotic hypothesis_2nd_revision.pdf
- Size:
- 306.87 KB
- Format:
- Adobe Portable Document Format