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Publicação
Chemiosmotic misunderstandings
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Autores
Orientador(es)
Resumo(s)
Recent publications have questioned the appropriateness of the chemiosmotic theory, a key tenet of
modern bioenergetics originally described by Mitchell and since widely improved upon and
applied. In one of them, application of Gauss’ law to a model charge distribution in mitochondria
was argued to refute the possibility of ATP generation through H+
movement in the absence of a
counterion, whereas a different author advocated, for other reasons, the impossibility of
chemiosmosis and proposed that a novel energy-generation scheme (referred to as “murburn”)
relying on superoxide-catalyzed (or superoxide-promoted) ADP phosphorylation would operate
instead. In this letter, those proposals are critically examined and found to be inconsistent with
established experimental data and new theoretical calculations.
Descrição
Palavras-chave
Bioenergetics Chemiosmosis Gauss’s law Proton-motive force
Contexto Educativo
Citação
Editora
Elsevier