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Insights into protein-ionic liquid interactions aiming at macromolecule delivery systems

2018Journal article Open access
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dc.contributor.authorHarada, Liliam
dc.contributor.authorPereira, Jorge
dc.contributor.authorCampos, Welida
dc.contributor.authorSilva, Erica
dc.contributor.authorMoutinho, Carla
dc.contributor.authorVila, Marta
dc.contributor.authorOliveira Jr., José
dc.contributor.authorTeixeira, José
dc.contributor.authorBalcão, Victor
dc.contributor.authorTubino, Matthieu
dc.date.accessioned2019-12-24T12:23:43Z
dc.date.available2019-12-24T12:23:43Z
dc.date.issued2018
dc.description.abstractOver the last few years, researchers have started to explore a particular class of compounds defined as ionic liquids (ILs) in attempts to use their unique characteristics. Since ILs have a very low vapor pressure, these fascinating compounds hold great potential as high performance chemicals for several applications in the (bio)pharmaceutical industry. In general, and unlike common organic solvents with comparable polarities, ILs are quite compatible with enzymes (enhancing their structural and chemical stability) and other proteins, since they can promote higher selectivities, faster reaction rates and greater enzyme stabilities in biocatalytic reactions providing, at the same time, a path for the structural and functional stabilization of protein entities. ILs appear to enhance the delivery of macromolecules, particularly protein entities, and their interactions with ILs will be tackled in detail in this review paper.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationHarada, L. K.; Pereira, J. F. B.; Campos, W. F.; Silva, E. C.; Moutinho, Carla G.; Vila, M. M. D. C.; Oliveira, J. M. , Jr.; Teixeira, José A.; Balcão, Victor M.; Tubino, M., Insights into protein-ionic liquid interactions aiming at macromolecule delivery systems. Journal of the Brazilian Chemical Society, 29(10), 1983-1998, 2018pt_PT
dc.identifier.doi10.21577/0103-5053.20180141pt_PT
dc.identifier.issn0103-5053
dc.identifier.urihttp://hdl.handle.net/10284/8341
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherSociedade Brasileira de Químicapt_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectIonic liquidspt_PT
dc.subjectStructural and functional stabilizationpt_PT
dc.subjectProtein stabilitypt_PT
dc.subjectBiopharmaceutical applicationspt_PT
dc.subjectTransdermal drug deliverypt_PT
dc.titleInsights into protein-ionic liquid interactions aiming at macromolecule delivery systemspt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage1998pt_PT
oaire.citation.startPage1983pt_PT
oaire.citation.titleJournal of the Brazilian Chemical Societypt_PT
oaire.citation.volume29pt_PT
person.familyNameMoutinho
person.familyNameBalcão
person.givenNameCarla
person.givenNameVictor
person.identifier366700
person.identifier.ciencia-idB61F-F356-80C6
person.identifier.ciencia-idC314-A18C-931B
person.identifier.orcid0000-0003-1310-4696
person.identifier.orcid0000-0003-0772-2834
person.identifier.ridM-7142-2013
person.identifier.ridI-2182-2012
person.identifier.scopus-author-id16064733800
person.identifier.scopus-author-id6603449856
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublicationcff7638e-1f33-4384-aa73-d3acc5cca5f8
relation.isAuthorOfPublicationf84a6560-46a5-4a51-91e4-25ab97dd1319
relation.isAuthorOfPublication.latestForDiscoverycff7638e-1f33-4384-aa73-d3acc5cca5f8

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