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Publicação
Insights into protein-ionic liquid interactions aiming at macromolecule delivery systems
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Orientador(es)
Resumo(s)
Over the last few years, researchers have started to explore a particular class of compounds
defined as ionic liquids (ILs) in attempts to use their unique characteristics. Since ILs have a very
low vapor pressure, these fascinating compounds hold great potential as high performance chemicals
for several applications in the (bio)pharmaceutical industry. In general, and unlike common organic
solvents with comparable polarities, ILs are quite compatible with enzymes (enhancing their
structural and chemical stability) and other proteins, since they can promote higher selectivities,
faster reaction rates and greater enzyme stabilities in biocatalytic reactions providing, at the same
time, a path for the structural and functional stabilization of protein entities. ILs appear to enhance
the delivery of macromolecules, particularly protein entities, and their interactions with ILs will
be tackled in detail in this review paper.
Descrição
Palavras-chave
Ionic liquids Structural and functional stabilization Protein stability Biopharmaceutical applications Transdermal drug delivery
Contexto Educativo
Citação
Harada, L. K.; Pereira, J. F. B.; Campos, W. F.; Silva, E. C.; Moutinho, Carla G.; Vila, M. M. D. C.; Oliveira, J. M. , Jr.; Teixeira, José A.; Balcão, Victor M.; Tubino, M., Insights into protein-ionic liquid interactions aiming at macromolecule delivery systems. Journal of the Brazilian Chemical Society, 29(10), 1983-1998, 2018
Editora
Sociedade Brasileira de Química