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Biochemical mechanisms of the effect of environmental factors (diet, fluorine, alcohol and tobacco) on oral health
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Orientador(es)
Resumo(s)
Nowadays, oral diseases are prevalent chronic diseases present in worldwide population. Dental caries results
from a complex interaction between acid-producing bacteria, fermentable carbohydrates and host factors,
including teeth and saliva. Risk factors for caries development include physical, biological, environmental,
behavioral factors such as high numbers of cariogenic bacteria, inadequate salivary flow, poor oral hygiene and
poor eating habits. Moreover, due to its efficacy in caries prevention, fluorine has been added to toothpaste,
supplements and water. However, despite of its beneficial effect, excessive intake can lead to acute or chronic
toxic effects, that depend on ingestion period and ingested amount, age, cardiovascular or renal problems and
genetic changes. The most common adverse effects of excessive fluorine intake are dental and skeletal fluorosis.
Another oral health problem is oral cancer, one of the most common cancers in the world and a highly relevant
problem of global public health, mainly affecting lips and oral cavity. It is a preventable disease, where tobacco
and alcohol, considered major risk factors, are present with a synergic effect in 90% of cases. Alcohol can act as a
risk factor both locally and systemically, being causally associated with oropharyngeal and larynx cancer,
esophageal cancer, among others.
Descrição
Palavras-chave
Caries Diet Fluorine Oral cancer Alcohol drinking