Loading...
Publication
Avaliação das propriedades biológicas de bioactive glass enquanto material restaurador: revisão sistemática
| Name: | Description: | Size: | Format: | |
|---|---|---|---|---|
| Projeto de pós-graduação_39688 | 612.16 KB | Adobe PDF |
Authors
Advisor(s)
Abstract(s)
Na área da Dentística há uma demanda constante do material restaurador da estrutura dentária ideal, tendo por base o seu potencial terapêutico, estético e longevidade. Recentemente, com a evolução dos materiais, novas alternativas aos materiais restauradores convencionais foram implementadas na prática clínica. Materiais biocerâmicos, especificamente o Bioactive Glass (BAG), potenciam a capacidade de remineralização de esmalte e dentina, assim como possuem um efeito antibacteriano contra as bactérias mais comummente encontradas na cavidade oral. O objetivo do presente estudo foi realizar uma revisão sistemática da literatura disponível, visando reunir e avaliar comparativamente resultados relacionados com as propriedades biológicas nomeadamente a citotoxicidade, a remineralização dentinária e do esmalte e as propriedades antibacterianas do BAG.
Materiais e métodos: Pesquisa e análise de artigos científicos presentes nas bases de dados online PubMed, ScienceDirect, Cochrane Central Register of Controlled Trials (CENTRAL), empregando a seguinte combinação de termos MeSH: “(Bioactive glasses) AND (Enamel Remineralization) AND (Dentin remineralization) AND (Toxicity) AND (Antibacterial) AND (Dental restoration)”. Foram estabelecidos os seguintes critérios de inclusão: (1) estudos nos quais o BAG foi aplicado enquanto material restaurador, adicionado a compósitos ou adesivos, independentemente da formulação; (2) estudos com indicação objetiva das propriedades biológicas a avaliar; (3) realização de follow-up com referência clara do método de reavaliação aplicado. E os seguintes critérios de exclusão: (1) estudos nos quais a aplicação de BAG foi efetuada com outros fins que não a restauração da estrutura dentária; (2) estudos envolvendo outros materiais bioativos além do BAG; (3) estudos onde o BAG foi incorporado em materiais de restauração provisória; (4) estudos em que o BAG foi utilizado em dentífricos; (5) estudos em dentes animais; (6) estudos não submetidos a peer review.
Não foram aplicadas restrições de idioma. Os critérios de elegibilidade para a elaboração desta revisão seguiram a estratégia PICO: Participantes - dentes humanos permanentes com lesões de desmineralização; Intervenção - Aplicação de materiais restauradores biocerâmicos do tipo BAG na estrutura dentária; Controlo - Comparação com outros materiais e/ou produtos que não sejam BAG, incluindo tratamentos placebo; Outcome - Avaliação dos comportamentos biológicos (remineralização da estrutura dentária, toxicidade e potencial antibacteriano) do BAG. A avaliação da qualidade e relevância dos resultados dos artigos in vitro selecionados foi realizada por meio das ferramentas de avaliação crítica do QUIN.
Resultados: Considerando uma pesquisa sistemática, com critérios de inclusão e exclusão definidos, foi possível identificar os processos em que as propriedades biológicas como a remineralização do esmalte e da dentina, o efeito antibacteriano e a baixa citotoxicidade do BAG se provaram vantajosos para a sua aplicação numa restauração biomimética do dente.
Conclusão: A capacidade de remineralização da estrutura dentária e o efeito antimicrobiano do BAG estão comprovados. No entanto, apesar da sua biocompatibilidade estar demonstrada em certos artigos, é imperativo explorar mais o seu efeito citotóxico ao ser utilizado em restaurações com resinas compostas.
In the field of Dentistry there is a constant search for the ideal dental structure restorative material, based on its therapeutic, aesthetic and longevity potential. Recently, with the evolution of material development, new alternatives to restorative materials were invented in a way to improve clinical practice. Bioceramic materials, specifically Bioactive Glass (BAG), enhance the remineralization capacity of enamel and dentin, as well as having an antibacterial effect against the most commonly found bacteria in the oral cavity. The objective of the present study was to carry out a systematic review of the available literature, gather and comparatively evaluate results related to the biological properties, namely cytotoxicity, dentin and enamel remineralization and antibacterial properties of BAG. Materials and methods: Search and analysis of scientific articles presented in the online databases PubMed, ScienceDirect, Cochrane Central Register of Controlled Trials (CENTRAL), using the following combination of MeSH terms: “(Bioactive Glasses) AND (Enamel remineralization) AND (Dentin remineralization) AND (Toxicity) AND (Antibacterial) AND (Dental restoration)”. The following inclusion criteria were established: (1) studies in which BAG was applied as a restorative material, added to composites or adhesives, regardless of the formulation; (2) studies with objective indication of the biological properties to be evaluated; (3) carrying out follow-up with clear reference to the reassessment method applied. And the following exclusion criteria: (1) studies in which the application of BAG was carried out for purposes other than the restoration of the tooth structure; (2) studies involving bioactive materials other than BAG; (3) studies where BAG was incorporated into temporary restoration materials; (4) studies in which BAG was used in toothpastes; (5) studies on animal teeth; (6) studies not subject to peer review. No language restrictions were applied. The eligibility criteria for the preparation of this review followed the PICO strategy: Participants - permanent human teeth with demineralization lesions; Intervention - Application of BAG-type bioceramic restorative materials to the dental structure; Control - Comparison with materials and/or products that are not BAGs, including placebo treatments; Results - Assessment of the biological behaviors (remineralization of the tooth structure, toxicity and antibacterial potential) of BAG. The assessment of the quality and relevance of the results of the selected in vitro articles was carried out using the QUIN critical assessment tools. Results: Considering a systematic research, with defined inclusion and exclusion criteria, it was possible to identify the processes in which biological properties such as the remineralization of enamel and dentin, the antibacterial effect and the low cytotoxicity of BAG were advantageous for its application in a biomimetic tooth restoration. Conclusion: The ability to remineralize the tooth structure and the antimicrobial effect of BAG are proven. However, despite its biocompatibility being demonstrated in certain articles, it is imperative to further explore its cytotoxic effect when used in composite resin restorations.
In the field of Dentistry there is a constant search for the ideal dental structure restorative material, based on its therapeutic, aesthetic and longevity potential. Recently, with the evolution of material development, new alternatives to restorative materials were invented in a way to improve clinical practice. Bioceramic materials, specifically Bioactive Glass (BAG), enhance the remineralization capacity of enamel and dentin, as well as having an antibacterial effect against the most commonly found bacteria in the oral cavity. The objective of the present study was to carry out a systematic review of the available literature, gather and comparatively evaluate results related to the biological properties, namely cytotoxicity, dentin and enamel remineralization and antibacterial properties of BAG. Materials and methods: Search and analysis of scientific articles presented in the online databases PubMed, ScienceDirect, Cochrane Central Register of Controlled Trials (CENTRAL), using the following combination of MeSH terms: “(Bioactive Glasses) AND (Enamel remineralization) AND (Dentin remineralization) AND (Toxicity) AND (Antibacterial) AND (Dental restoration)”. The following inclusion criteria were established: (1) studies in which BAG was applied as a restorative material, added to composites or adhesives, regardless of the formulation; (2) studies with objective indication of the biological properties to be evaluated; (3) carrying out follow-up with clear reference to the reassessment method applied. And the following exclusion criteria: (1) studies in which the application of BAG was carried out for purposes other than the restoration of the tooth structure; (2) studies involving bioactive materials other than BAG; (3) studies where BAG was incorporated into temporary restoration materials; (4) studies in which BAG was used in toothpastes; (5) studies on animal teeth; (6) studies not subject to peer review. No language restrictions were applied. The eligibility criteria for the preparation of this review followed the PICO strategy: Participants - permanent human teeth with demineralization lesions; Intervention - Application of BAG-type bioceramic restorative materials to the dental structure; Control - Comparison with materials and/or products that are not BAGs, including placebo treatments; Results - Assessment of the biological behaviors (remineralization of the tooth structure, toxicity and antibacterial potential) of BAG. The assessment of the quality and relevance of the results of the selected in vitro articles was carried out using the QUIN critical assessment tools. Results: Considering a systematic research, with defined inclusion and exclusion criteria, it was possible to identify the processes in which biological properties such as the remineralization of enamel and dentin, the antibacterial effect and the low cytotoxicity of BAG were advantageous for its application in a biomimetic tooth restoration. Conclusion: The ability to remineralize the tooth structure and the antimicrobial effect of BAG are proven. However, despite its biocompatibility being demonstrated in certain articles, it is imperative to further explore its cytotoxic effect when used in composite resin restorations.
Description
Keywords
Bioactive Glass Material biocerâmico Remineralização Efeito antimicrobiano Toxicidade Dentística Bioceramic material Remineralization Antimicrobial effect Toxicity Dentistry