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Overview on gastroretentive drug delivery systems for improving drug bioavailability
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Orientador(es)
Resumo(s)
In recent decades, many efforts have been made in order to improve drug bioavailability after oral
administration. Gastroretentive drug delivery systems are a good example; they emerged to enhance the
bioavailability and effectiveness of drugs with a narrow absorption window in the upper gastrointestinal
tract and/or to promote local activity in the stomach and duodenum. Several strategies are used to
increase the gastric residence time, namely bioadhesive or mucoadhesive systems, expandable systems,
high-density systems, floating systems, superporous hydrogels and magnetic systems. The present
review highlights some of the drugs that can benefit from gastroretentive strategies, such as the factors
that influence gastric retention time and the mechanism of action of gastroretentive systems, as well as
their classification into single and multiple unit systems.
Descrição
Palavras-chave
Narrow absorption window Controlled drug release Gastroretentive system Gastric retention time Multiple unit dosage form
Contexto Educativo
Citação
Editora
Elsevier