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Overview on gastroretentive drug delivery systems for improving drug bioavailability

dc.contributor.authorLopes, Carla Martins
dc.contributor.authorBettencourt, Catarina
dc.contributor.authorRossi, Alessandra
dc.contributor.authorButtini, Francesca
dc.contributor.authorBarata, Pedro
dc.date.accessioned2020-09-29T13:54:08Z
dc.date.available2020-09-29T13:54:08Z
dc.date.issued2016-08
dc.date.updated2020-07-24T15:21:29Z
dc.description.abstractIn recent decades, many efforts have been made in order to improve drug bioavailability after oral administration. Gastroretentive drug delivery systems are a good example; they emerged to enhance the bioavailability and effectiveness of drugs with a narrow absorption window in the upper gastrointestinal tract and/or to promote local activity in the stomach and duodenum. Several strategies are used to increase the gastric residence time, namely bioadhesive or mucoadhesive systems, expandable systems, high-density systems, floating systems, superporous hydrogels and magnetic systems. The present review highlights some of the drugs that can benefit from gastroretentive strategies, such as the factors that influence gastric retention time and the mechanism of action of gastroretentive systems, as well as their classification into single and multiple unit systems.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.doi10.1016/j.ijpharm.2016.05.016pt_PT
dc.identifier.eid2-s2.0-84976318120
dc.identifier.issn0378-5173
dc.identifier.slugcv-prod-337023
dc.identifier.urihttp://hdl.handle.net/10284/9010
dc.language.isoengpt_PT
dc.publisherElsevierpt_PT
dc.subjectNarrow absorption windowpt_PT
dc.subjectControlled drug releasept_PT
dc.subjectGastroretentive systempt_PT
dc.subjectGastric retention timept_PT
dc.subjectMultiple unit dosage formpt_PT
dc.titleOverview on gastroretentive drug delivery systems for improving drug bioavailabilitypt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage158pt_PT
oaire.citation.startPage144pt_PT
oaire.citation.titleInternational Journal of Pharmaceuticspt_PT
oaire.citation.volume510pt_PT
person.familyNameLopes
person.familyNameBarata
person.givenNameCarla
person.givenNamePedro
person.identifier1143078
person.identifier.ciencia-id901D-160C-633E
person.identifier.ciencia-id1A18-987D-45C3
person.identifier.orcid0000-0001-5080-032X
person.identifier.orcid0000-0002-4537-5450
person.identifier.ridM-4689-2016
person.identifier.scopus-author-id26649517700
person.identifier.scopus-author-id55043534700
rcaap.cv.cienciaid901D-160C-633E | Carla Martins Lopes
rcaap.rightsrestrictedAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublicationd2a48cfe-9258-4916-99be-bbcb710f6605
relation.isAuthorOfPublication8d0c119d-146f-4548-9e03-b16d0050ef08
relation.isAuthorOfPublication.latestForDiscoveryd2a48cfe-9258-4916-99be-bbcb710f6605

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