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Risco de cancro da cabeça e pescoço associado a manifestações orais da doença de Crohn: revisão sistemática
| Name: | Description: | Size: | Format: | |
|---|---|---|---|---|
| Projeto de pós-graduação_39803 | 1.95 MB | Adobe PDF |
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Abstract(s)
A doença de Crohn é descrita como uma doença inflamatória intestinal que afeta o trato gastrointestinal. As manifestações orais são frequentemente os primeiros sintomas desta patologia, que incluem úlceras aftosas, vermelhidão, edema e dor e surgem, principalmente, na mucosa, lábios e língua. Estas alterações podem evoluir para lesões que estão frequentemente associadas ao cancro de cabeça e pescoço.
O objetivo desta revisão sistemática é analisar se existe um risco aumentado do cancro de cabeça e pescoço associado às manifestações orais da doença de Crohn.
A identificação e seleção dos artigos foram realizadas com base em critérios de inclusão e exclusão previamente estabelecidos. Foram incluídos artigos publicados entre 2000 e março de 2024, escritos em inglês, francês ou português que relatam estudos em humanos e que respondam à questão PICO. Excluíram-se artigos que relatem estudos em animais ou in vitro, artigos escritos em outros idiomas e os que não estavam relacionados com o tema principal. As bases de dados utilizadas foram a PubMed, a Web of Science e a Biblioteca Virtual em Saúde. Assim, foram incluídos sete artigos que preenchiam os critérios definidos sendo três estudos de Coorte, dois estudos de casos controlo e dois relatos de caso.
Pela análise dos artigos, os doentes com doença de Crohn e manifestações orais parecem apresentar um risco mais elevado de desenvolver cancro da cabeça e do pescoço. Contudo, não existem trabalhos publicados suficientes que demonstrem claramente esta relação. Os trabalhos estudados referem que esta relação está principalmente associada ao grau de inflamação crónica, aos tratamentos imunossupressores e às manifestações orais. Em especial, os sintomas orais são sinais de alerta importantes e necessitam de uma atenção clínica específica para evitar a sua progressão para tumores malignos.
Crohn's disease is described as an inflammatory bowel disease that affects the gastrointestinal tract. Oral manifestations are often the first symptoms of this pathology, which include aphthous ulcers, redness, oedema and pain and appear mainly on the mucosa, lips and tongue. These changes can develop into lesions that are often associated with head and neck cancer. The aim of this systematic review is to analyze whether there is an increased risk of head and neck cancer associated with oral manifestations of Crohn's disease. The articles were identified and selected based on previously established inclusion and exclusion criteria. Articles published between 2000 and March 2024, written in English, French or Portuguese, reporting on human studies and answering the PICO question were included. Articles reporting on animal or in vitro studies, articles written in other languages and those unrelated to the main topic were excluded. The databases used were PubMed, Web of Science and the Virtual Health Library. Seven articles that met the criteria were included: three cohort studies, two case-control studies and two case reports. By analyzing the articles, patients with Crohn's disease and oral manifestations appear to be at a higher risk of developing head and neck cancer. However, there are not enough published studies that clearly demonstrate this relationship. The studies that have been carried out indicate that this relationship is mainly associated with the degree of chronic inflammation, immunosuppressive treatments and oral manifestations. In particular, oral symptoms are important warning signs and require specific clinical attention to prevent their progression to malignant tumors.
Crohn's disease is described as an inflammatory bowel disease that affects the gastrointestinal tract. Oral manifestations are often the first symptoms of this pathology, which include aphthous ulcers, redness, oedema and pain and appear mainly on the mucosa, lips and tongue. These changes can develop into lesions that are often associated with head and neck cancer. The aim of this systematic review is to analyze whether there is an increased risk of head and neck cancer associated with oral manifestations of Crohn's disease. The articles were identified and selected based on previously established inclusion and exclusion criteria. Articles published between 2000 and March 2024, written in English, French or Portuguese, reporting on human studies and answering the PICO question were included. Articles reporting on animal or in vitro studies, articles written in other languages and those unrelated to the main topic were excluded. The databases used were PubMed, Web of Science and the Virtual Health Library. Seven articles that met the criteria were included: three cohort studies, two case-control studies and two case reports. By analyzing the articles, patients with Crohn's disease and oral manifestations appear to be at a higher risk of developing head and neck cancer. However, there are not enough published studies that clearly demonstrate this relationship. The studies that have been carried out indicate that this relationship is mainly associated with the degree of chronic inflammation, immunosuppressive treatments and oral manifestations. In particular, oral symptoms are important warning signs and require specific clinical attention to prevent their progression to malignant tumors.
Description
Keywords
Doença de Crohn Manifestações orais Cancro cabeça e pescoço Crohn's disease Oral manifestations Head and neck cancer