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Novos sistemas terapêuticos para a administração de fármacos utilizados no tratamento de doenças neurodegenerativas: Alzheimer e Parkinson
| Name: | Description: | Size: | Format: | |
|---|---|---|---|---|
| PPG_23491 | 1.15 MB | Adobe PDF |
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Abstract(s)
Este trabalho foi realizado para conclusão do mestrado integrado em Ciências Farmacêuticas. Consiste na revisão relativa ao estado da arte dos fármacos e das formas farmacêuticas utilizadas para o tratamento de doenças neurodegenerativas, e dos avanços tecnológicos utilizados para a produção de sistemas terapêuticos alternativos e mais eficientes que as formas convencionais.
No início do trabalho é efetuada uma descrição do sistema nervoso central (SNC) ao nível das suas funções, estrutura e organização, bem como os mecanismos envolvidos no desenvolvimento de doenças, nomeadamente, a doença de Alzheimer e de Parkinson. De seguida, são apresentados diversos fármacos habitualmente utilizados no tratamento destas doenças, veiculados em formas farmacêuticas convencionais e em novos sistemas terapêuticos, que ainda se encontram em fase de desenvolvimento ou aprovação.
Esta revisão de literatura tem a intenção de analisar os tratamentos convencionais e terapias alternativas fornecidas pela nanomedicina para a doença de Alzheimer e doença de Parkinson.
This work was carried out to complete the integrated master's degree in Pharmaceutical Sciences. It consists in the review on the state of the art of drugs and pharmaceutical dosage forms used for the treatment of neurodegenerative diseases. Furthermore, a description of the technological advances used for the production of alternative and more efficient delivery systems is also presented. The work starts with a description of the central nervous system (CNS) regarding its functions, structure and organization, as well as the mechanisms involved in the development of Alzheimer's and Parkinson's disease. Subsequently, are presented several drugs commonly used to treat these diseases, which are available in conventional dosage forms, and examples of new therapeutic systems, which are under development or in approval processes. This literature review aims to analyze the conventional treatments and alternative therapies provided by nanomedicine for Alzheimer's and Parkinson's disease.
This work was carried out to complete the integrated master's degree in Pharmaceutical Sciences. It consists in the review on the state of the art of drugs and pharmaceutical dosage forms used for the treatment of neurodegenerative diseases. Furthermore, a description of the technological advances used for the production of alternative and more efficient delivery systems is also presented. The work starts with a description of the central nervous system (CNS) regarding its functions, structure and organization, as well as the mechanisms involved in the development of Alzheimer's and Parkinson's disease. Subsequently, are presented several drugs commonly used to treat these diseases, which are available in conventional dosage forms, and examples of new therapeutic systems, which are under development or in approval processes. This literature review aims to analyze the conventional treatments and alternative therapies provided by nanomedicine for Alzheimer's and Parkinson's disease.
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Keywords
Sistema nervoso central SNC Doença de Alzheimer Doença de Parkinson Formas farmacêuticas convencionais Novas sistemas terapêuticos Central nervous system CNS Alzheimer's disease Parkinson's disease Pharmaceutical conventional dosage forms New therapeutic systems