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Aplicação de fibrina rica em plaquetas na microcirurgia apical: revisão integrativa
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A microcirurgia apical endodôntica regenerativa, associada ao uso de fibrina rica em plaquetas (PRF), oferece uma abordagem inovadora no tratamento de lesões periapicais complexas, visto que a PRF estimula a regeneração óssea e a cicatrização dos tecidos por meio da libertação de fatores de crescimento e citocinas que promovem a regeneração óssea e dos tecidos moles. Além disso, a matriz de fibrina desempenha um papel importante na regulação imunológica e na angiogénese. O objetivo desta revisão integrativa foi analisar e sintetizar as evidências científicas disponíveis sobre o sucesso da aplicação da PRF na microcirurgia apical endodôntica regenerativa no tratamento de lesões apicais complexas. Para isso, foi realizada uma pesquisa bibliográfica nas bases de dados PubMed, Scielo e ScienceDirect, utilizando várias palavras-chave combinadas entre si. Após a aplicação dos critérios de inclusão e exclusão, foram selecionados 10 artigos, que constituem os resultados desta revisão. Os estudos analisados demonstraram que o uso do L-PRF na microcirurgia endodôntica é seguro e eficaz, apresentando resultados clínicos promissores. A aplicação da PRF mostrou-se vantajosa em contextos clínicos específicos, onde suas propriedades podem significativamente apoiar o processo de cicatrização, acelerando a regeneração óssea e a recuperação dos tecidos moles. Porém, apesar dos resultados positivos, há uma necessidade de mais estudos clínicos controlados, com amostras representativas e protocolos padronizados. Isso permitirá validar a eficácia do PRF de forma mais robusta e determinar os melhores protocolos para sua aplicação, consolidando a PRF como uma ferramenta terapêutica essencial na prática endodôntica regenerativa.
Regenerative endodontic apical microsurgery, combined with the use of platelet-rich fibrin (PRF), offers an innovative approach to the treatment of complex periapical lesions, as PRF stimulates bone regeneration and tissue healing through the release of growth factors and cytokines that promote both bone and soft tissue regeneration. Additionally, the fibrin matrix plays a crucial role in immune regulation and angiogenesis. The aim of this integrative review was to analyze and synthesize the available scientific evidence regarding the success of PRF application in regenerative endodontic apical microsurgery for the treatment of complex apical lesions. A bibliographic search was conducted in PubMed, Scielo, and ScienceDirect databases using various combined keywords. After applying the inclusion and exclusion criteria, 10 articles were selected, which constitute the results of this review. The analyzed studies demonstrated that the use of L-PRF in endodontic microsurgery is safe and effective, presenting promising clinical outcomes. PRF application proved to be advantageous in specific clinical contexts where its properties can significantly contribute to the healing process, accelerating bone regeneration and soft tissue recovery. However, despite the positive results, there is a need for more controlled clinical studies with representative samples and standardized protocols. Such studies will enable a more robust validation of PRF efficacy and the establishment of optimal application protocols, ultimately consolidating PRF as an essential therapeutic tool in regenerative endodontic practice.
Regenerative endodontic apical microsurgery, combined with the use of platelet-rich fibrin (PRF), offers an innovative approach to the treatment of complex periapical lesions, as PRF stimulates bone regeneration and tissue healing through the release of growth factors and cytokines that promote both bone and soft tissue regeneration. Additionally, the fibrin matrix plays a crucial role in immune regulation and angiogenesis. The aim of this integrative review was to analyze and synthesize the available scientific evidence regarding the success of PRF application in regenerative endodontic apical microsurgery for the treatment of complex apical lesions. A bibliographic search was conducted in PubMed, Scielo, and ScienceDirect databases using various combined keywords. After applying the inclusion and exclusion criteria, 10 articles were selected, which constitute the results of this review. The analyzed studies demonstrated that the use of L-PRF in endodontic microsurgery is safe and effective, presenting promising clinical outcomes. PRF application proved to be advantageous in specific clinical contexts where its properties can significantly contribute to the healing process, accelerating bone regeneration and soft tissue recovery. However, despite the positive results, there is a need for more controlled clinical studies with representative samples and standardized protocols. Such studies will enable a more robust validation of PRF efficacy and the establishment of optimal application protocols, ultimately consolidating PRF as an essential therapeutic tool in regenerative endodontic practice.
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Palavras-chave
Cirurgia endodôntica Microcirurgia apical Fibrina rica em plaquetas Lesão periapical Endodontic surgery Apical microsurgery Platelet-rich fibrin Periapical lesion