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Publication
Metabolitos secundários das macroalgas castanhas de elevado potencial para a indústria farmacêutica
| Name: | Description: | Size: | Format: | |
|---|---|---|---|---|
| PPG_18663 | 1.7 MB | Adobe PDF |
Advisor(s)
Abstract(s)
Nos últimos anos, a procura por novos compostos para utilização pela indústria
farmacêutica conduziu a um aumento dos estudos com espécies marinhas, uma vez que a
sua aplicabilidade para fins terapêuticos é conhecida por parte de comunidades costeiras
desde tempos remotos.
O ambiente marinho tem evidenciado uma grande biodiversidade de espécies que
demonstraram possuir a capacidade de sintetizar vários compostos com elevado potencial
farmacológico. Assim, a indústria farmacêutica tem investido na extração, identificação
e estudos de várias moléculas que constituem metabolitos de espécies marinhas, algumas
das quais não podem ser encontradas em plantas terrestres
As macroalgas foram, entre outras espécies, alvo desses estudos e provaram a sua
importância como fonte de compostos bioativos. Dentro das macroalgas as
Phaeophyceae, macroalgas castanhas, têm vindo a demonstrar ter metabolitos como por
exemplo os polissacarídeos, os florotaninos, os carotenoides e os esteróis com grande
interesse para a indústria farmacêutica.
Os metabolitos das macroalgas castanhas possuem várias atividades farmacológicas, tais
como atividade antioxidante, anti-tumoral, antifúngica, antivírica ou antibacteriana entre
outras, o que pode constituir uma mais valia no desenvolvimento de novos fármacos.
Atualmente, existem no mercado produtos, principalmente suplementos e produtos
cosméticos, contendo extratos de macroalgas castanhas, mas é necessária mais pesquisa
para se compreender na totalidade as propriedades e aplicabilidades de todos os
compostos obtidos destes organismos marinhos.
In recent years, the demand for new compounds for use by the pharmaceutical industry has led to an increase in studies with marine species, since their applicability for therapeutic purposes has been known by coastal communities since remote times. The marine environment has shown great biodiversity of species that have demonstrated the ability to synthesize various compounds with high pharmacological potential. Thus, the pharmaceutical industry has invested in the extraction, identification, and studies of various molecules that constitute metabolites of marine species, some of which cannot be found in terrestrial plants. Macroalgae were, among other species, the target of these studies and proved their importance as a source of bioactive compounds. Within the macroalgae, Phaeophyceae, brown macroalgae, have been shown to have metabolites such as polysaccharides, phlorotannins, carotenoids, and sterols with a great interest for the pharmaceutical industry. The metabolites of brown macroalgae have several pharmacological activities, such as antioxidant, anti-tumor, antifungal, antiviral or antibacterial activity, among others, which can be an asset in the development of new drugs. Currently, there are products on the market, mainly supplements and cosmetic products, containing extracts of brown macroalgae, but more research is needed to fully understand the properties and applicability of all compounds obtained from these marine organisms.
In recent years, the demand for new compounds for use by the pharmaceutical industry has led to an increase in studies with marine species, since their applicability for therapeutic purposes has been known by coastal communities since remote times. The marine environment has shown great biodiversity of species that have demonstrated the ability to synthesize various compounds with high pharmacological potential. Thus, the pharmaceutical industry has invested in the extraction, identification, and studies of various molecules that constitute metabolites of marine species, some of which cannot be found in terrestrial plants. Macroalgae were, among other species, the target of these studies and proved their importance as a source of bioactive compounds. Within the macroalgae, Phaeophyceae, brown macroalgae, have been shown to have metabolites such as polysaccharides, phlorotannins, carotenoids, and sterols with a great interest for the pharmaceutical industry. The metabolites of brown macroalgae have several pharmacological activities, such as antioxidant, anti-tumor, antifungal, antiviral or antibacterial activity, among others, which can be an asset in the development of new drugs. Currently, there are products on the market, mainly supplements and cosmetic products, containing extracts of brown macroalgae, but more research is needed to fully understand the properties and applicability of all compounds obtained from these marine organisms.
Description
Keywords
Macroalgas castanhas Metabolitos secundários Florotaninos Polifenol Algas marinhas Compostos bioativos Antioxidante Antifúngico Antivírico Antitumoral Antibacteriano Brown seaweeds Secondary metabolites Phlorotannins Polyphenol Marine algae Bioactive compounds Antioxidant Antifungal Antiviral Antitumoral Antibacterial