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Estudo da doença celíaca
| Name: | Description: | Size: | Format: | |
|---|---|---|---|---|
| PPG_24523 | 2.4 MB | Adobe PDF |
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Advisor(s)
Abstract(s)
A Doença Celíaca (DC) é uma doença auto-imune que ocorre em indivíduos com
predisposição genética causada pela permanente sensibilidade ao glúten. A ingestão do
glúten vai provocar alterações típicas no intestino que impedem a absorção normal dos
nutrientes, e é característico da doença o desaparecimento dessas lesões quando se faz
uma dieta isenta de glúten.
Os estudos de prevalência da DC têm demonstrado que esta doença é mais comum do que
anteriormente se acreditava, ainda assim esta é subestimada dada a falta de informação
sobre a doença e a dificuldade de acesso aos meios de diagnóstico que reduzem as
possibilidades de tratamento adequado e consequente melhoria clínica. Estudos revelam
que o problema atinge pessoas de todas as idades.
Devido ao caráter hereditário, parentes de primeiro grau de celíacos devem ser
submetidos ao teste sorológico para sua deteção entre as quatro formas de apresentação
clínica da DC que são: clássica ou típica, não clássica ou atípica, assintomática ou
silenciosa e latente.
Atualmente, o tratamento mais aceite consiste numa dieta isenta em glúten (DIG) para
toda a vida. A mesma deve ser rigorosa, saudável e equilibrada, não devendo os alimentos
que contêm glúten ser eliminados, mas sim substituídos por outros cujas matérias-primas
não o contêm. Apenas a eliminação do glúten da alimentação permite que o intestino
regenere por completo da lesão e o organismo recupere. Contudo, se houver reintrodução
do glúten, as inflamações regressam e os sintomas reaparecem.
Com o avançar da ciência novos horizontes têm sido abertos, sendo as hipóteses atuais
mais próximas de efetivação a vacina, que curaria (ao contrário da maior das vacinas que
apenas previne) a DC, e os comprimidos que permitiriam que o celíaco pudesse ingerir
glúten sem uma resposta negativa do seu organismo. Nesta revisão, serão abordados todos os aspetos importantes desta doença com o objetivo
de rever toda a informação relevante da doença até á data.
Este projeto de dissertação terá por base revisão bibliográfica de pesquisas realizadas com
motores de busca como B-on, Pubmed, e Science Direct.
Celiac Disease (CD) is an autoimmune disease that occurs in individuals with genetic predisposition caused by permanent sensitivity to gluten. Intake of gluten will cause typical changes in the gut that prevent the normal absorption of nutrients, and it is characteristic of the disease the disappearance of these lesions when doing a gluten-free diet. Studies of the prevalence of CD have shown that this disease is more common than previously believed, yet it is underestimated given the lack of information about the disease and the difficulty of access to the means of diagnosis that reduce the possibilities of adequate treatment and consequent clinical improvement. Studies reveal that the problem reaches people of all ages. Due to their hereditary nature, first-degree relatives of celiac patients should be submitted to the serological test for their detection among the four forms of clinical presentation of CD that are: classical or typical, nonclassical or atypical, asymptomatic or silent and latent. Currently, the most accepted treatment is a gluten-free diet (DIG) for life. It must be strict, healthy and balanced, and foods containing gluten should not be eliminated but replaced by foods whose raw materials do not contain it. Only the elimination of gluten from the diet allows the intestine to regenerate completely from the injury and the body recovers. However, if gluten is reintroduced, inflammation returns and symptoms reappear. With the advancement of science new horizons have been opened, the current hypotheses being closer to effective the vaccine, which would cure (as opposed to the largest of the vaccines it only prevents) CD, and tablets that would allow celiac to ingest gluten without negative response from your body. In this review, all important aspects of this disease will be addressed in order to review all the relevant information of the disease to date. This dissertation project will be based on a bibliographic review of research conducted with search engines such as B-on, Pubmed, and Science Direct.
Celiac Disease (CD) is an autoimmune disease that occurs in individuals with genetic predisposition caused by permanent sensitivity to gluten. Intake of gluten will cause typical changes in the gut that prevent the normal absorption of nutrients, and it is characteristic of the disease the disappearance of these lesions when doing a gluten-free diet. Studies of the prevalence of CD have shown that this disease is more common than previously believed, yet it is underestimated given the lack of information about the disease and the difficulty of access to the means of diagnosis that reduce the possibilities of adequate treatment and consequent clinical improvement. Studies reveal that the problem reaches people of all ages. Due to their hereditary nature, first-degree relatives of celiac patients should be submitted to the serological test for their detection among the four forms of clinical presentation of CD that are: classical or typical, nonclassical or atypical, asymptomatic or silent and latent. Currently, the most accepted treatment is a gluten-free diet (DIG) for life. It must be strict, healthy and balanced, and foods containing gluten should not be eliminated but replaced by foods whose raw materials do not contain it. Only the elimination of gluten from the diet allows the intestine to regenerate completely from the injury and the body recovers. However, if gluten is reintroduced, inflammation returns and symptoms reappear. With the advancement of science new horizons have been opened, the current hypotheses being closer to effective the vaccine, which would cure (as opposed to the largest of the vaccines it only prevents) CD, and tablets that would allow celiac to ingest gluten without negative response from your body. In this review, all important aspects of this disease will be addressed in order to review all the relevant information of the disease to date. This dissertation project will be based on a bibliographic review of research conducted with search engines such as B-on, Pubmed, and Science Direct.
Description
Keywords
Doença celíaca Glúten Testes serológicos Gliadina Transglutaminase tecidular Celiac disease Gluten Serological tests Gliadin Tissue transglutaminase